Validation of a passive sampler for ketones

Details

• Personal Author:
  Que Hee-S ; Tsai-S
• Description:
  O-(2.3,4.5.6-pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA) has been used to analyze aldehydes in water because of its fast quantitative reaction to form oximes suitable for detection at the picogram (pg) level by gas chromatography/mass spectrometry (GCIMS) and gas chromatography/electron capture detection (GC/ECD). The PFBHA method also has been used to chemisorb aldehydes in air samples by dynamic sampling as well as passive sampling. The present aim was to validate a new ketones passive sampler for personal sampling in the environmental/industrial hygiene field. Cyclohexanone, diethyl ketone, ethyl butyl ketone, methyl n-amyl ketone, methyl n-butyl ketone, methyl ethyl ketone, methyl isopropyl ketone, and methyl propyl ketone were tested. A 13-mm diameter and 0.2-cm-thick pellet of PFBHA coated Tenax GC (1 0%, w/w) was made by a hand press. The sampler has a silicone membrane on top and a diffusion path length of 1.1 cm. The sampling constant was determined by exposures at known face velocities (20 to 70 fpm) at known vapor concentrations about the permissible exposure limit (PEL) as generated by a syringe pump at constant injection rate into pure air of known flow rate, and diluted appropriately before the exposure chamber. The PFBHA-ketone oximes were desorbed by hexane, and determined by selected ion monitoring GC/MS at m/z 181. The desorption efficiencies for wet ketones spiking were 87.2 +/- 7.0%, cyclohexanone; 91.1 +/- 3.9%, diethyl ketone; 98.0 +/- 3.2%, ethyl butyl ketone; 93.3 +/- 2.7%, methyl n-amyl ketone; 107.00 +/- 0.14%, methyl n-butyl ketone; 90.0 +/- 4.0%, methyl ethyl ketone; 92.8 +/- 5.6%, methyl isopropyl ketone; and 92.5 +/- 2.6%, methyl propyl ketone. The experimental sampling rates in mL/min were 4.07 +/- 0.49. cyclohexanone; 6.30 +/- 0.59, diethyl ketone; 6.31 +/- 0.31, ethyl butyl ketone; 3.78 +/- 0.25, methyl n-amyl ketone; 3.43 +/- 0.19, methyl n-butyl ketone; 6.48 +/- 0.64, methyl ethyl ketone; 4.37 +/- 0.43, methyl isopropyl ketone; and 4.57 +/- 0.17, methyl propyl ketone. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Environmental Exposure Environmental Health Environmental Monitoring Laboratories Manufacturing And Industrial Facilities Mass Spectrometry Occupational Health Particulate Matter Safety Volatilization

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• Keywords:
  Air-monitoring Air-samples Air-sampling Air-sampling-techniques Airborne-particles Environmental-exposure Exposure-assessment Gas-chromatography Indoor-environmental-quality Industrial-environment Laboratory-testing Mass-spectrometry Quantitative-analysis Sampling-methods Statistical-analysis Vapor-detectors Vapor-volume Water-sampling

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• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Georgia ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  20
• NIOSHTIC Number:
  nn:20039240
• Citation:
  American Industrial Hygiene Conference and Exposition, June 5-11, 1999, Toronto, Ontario, Canada. Fairfax, VA: American Industrial Hygiene Association, 1999 Jun; :20
• CAS Registry Number:
  2-Heptanone (CAS RN 110-43-0) ; 2-Hexanone (CAS RN 591-78-6) ; 2-Pentanone (CAS RN 107-87-9) ; Cyclohexanone (CAS RN 108-94-1) ; Ethyl ketone (CAS RN 96-22-0) ; Methyl ethyl ketone (CAS RN 78-93-3) ; Methyl isobutyl ketone (CAS RN 108-10-1)
• Federal Fiscal Year:
  1999
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of California Los Angeles, Los Angeles, CA
• Peer Reviewed:
  False
• Start Date:
  19950901
• Source Full Name:
  American Industrial Hygiene Conference and Exposition, June 5-11, 1999, Toronto, Ontario, Canada
• End Date:
  19990831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:27a19cf71ee7a2a87661721ada90efac7ad4db822ad159bc7e1dcdeadf8ae653298013908c52c7ef71c607d1237ea62a642fb470f14807f3f3b90be2c10335a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/192654/cdc_192654_DS1.pdf
• File Type:
  [PDF - 969.20 KB ]