Genetic variability in susceptibility to occupational respiratory sensitization

Details

• Personal Author:
  Johnson VJ ; Yucesoy, Berran
• Description:
  Respiratory sensitization can be caused by a variety of substances at workplaces, and the health and economic burden linked to allergic respiratory diseases continues to increase. Although the main factors that affect the onset of the symptoms are the types and intensity of allergen exposure, there is a wide range of interindividual variation in susceptibility to occupational/environmental sensitizers. A number of gene variants have been reported to be associated with various occupational allergic respiratory diseases. Examples of genes include, but are not limited to, genes involved in immune/inflammatory regulation, antioxidant defenses, and fibrotic processes. Most of these variants act in combination with other genes and environmental factors to modify disease progression, severity, or resolution after exposure to allergens. Therefore, understanding the role of genetic variability and the interaction between genetic and environmental/occupational factors provides new insights into disease etiology and may lead to the development of novel preventive and therapeutic strategies. This paper will focus on the current state of knowledge regarding genetic influences on allergic respiratory diseases, with specific emphasis on diisocyanate-induced asthma and chronic beryllium disease. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Genetics Hypersensitivity Immune System Irritants Lung Occupational Health Respiratory Hypersensitivity Respiratory System Safety
• Keywords:
  Allergic-reactions Allergies Exposure-assessment Exposure-levels Genetic-factors Immune-reaction Immune-system-disorders Lung-irritants Pulmonary-function Pulmonary-system Quantitative-analysis Respiratory-hypersensitivity Respiratory-irritants

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• ISSN:
  1687-9783
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2011
• NIOSHTIC Number:
  nn:20039173
• Citation:
  J Allergy 2011 Apr; 2011:346719
• Contact Point Address:
  Berran Yucesoy, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Allergy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1361b776a07bc58445d91d24b035e9661868a716cad03ca99ff5096b13503250736a36699f8cffa7604658ca45012dbe88b42b6c3dd49dfd59bb60e46404f928
• Download URL:
  https://stacks.cdc.gov/view/cdc/192616/cdc_192616_DS1.pdf
• File Type:
  [PDF - 521.04 KB ]