Psychological distress, depressive symptoms, and cellular immunity among healthy individuals: a 1-year prospective study

Details

• Personal Author:
  Irie M ; Nakata A ; Takahashi M
• Description:
  Cross-sectional and case-control studies have reported that psychological distress and depression are associated with reduced cellular immune competence but the directionality of the relationship remains uncertain. This study investigated whether levels of psychological distress and depressive symptoms are related to subsequent changes in counts of lymphocyte subsets (natural killer (NK), B, and T cell) and/or whether changes of immune markers predict psychological distress/depressive symptoms in a 1-year prospective study design. A total of 105 healthy employees (67 men and 38 women), aged 23-59 (mean 40) years with an average of 15years of education, underwent a blood draw for the measurement of circulating immune cells and completed the Japanese version of the 28-item General Health Questionnaire (GHQ-28) and the Center for Epidemiologic Studies Depression Scale (CES-D) in April 2002 (time 1) and 2003 (time 2). Hierarchical multiple linear regression analyses revealed that GHQ-28 and CES-D scores at time 1 were significantly (p<.05) and inversely associated with NK cells at time 2 controlling for potential confounders including time 1 NK cells (β=-.221 and -.177, respectively). In contrast, NK cells and NK cell cytotoxicity at time 1 did not predict GHQ-28 or CES-D score at time 2 controlling for GHQ-28/CES-D score at time 1. GHQ-28 and CES-D scores were not related to T or B cells at times 1 and 2. The present findings indicate that psychological distress and depressive symptoms may precede and predict suppression of NK cell immunity while NK cells did not lead to subsequent psychological distress and depressive symptoms, suggesting an absence of the bi-directional relationships. [Description provided by NIOSH]
• Subjects:
  Aging Blood Immune System Mental Disorders Mental Health Occupational Health Safety Stress, Psychological Surveys And Questionnaires
• Keywords:
  Age-groups Author Keywords: Psychological Distress Cell-biology Cellular-reactions Depressive Symptoms Immune-reaction Immune-system Immune System Immunochemistry Immunology Lymphocyte Lymphocytes Mathematical-models Mental-health Mental-processes Mental-stress Natural Killer Cells Psychological-adaptation Psychological-disorders Psychological-effects Psychological-factors Psychological-processes Psychological-reactions Psychological-responses Psychological-stress Questionnaires Statistical-analysis

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• ISSN:
  0167-8760
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  191-197
• Volume:
  81
• Issue:
  3
• NIOSHTIC Number:
  nn:20039172
• Citation:
  Int J Psychophysiol 2011 Sep; 81(3):191-197
• Contact Point Address:
  Akinori Nakata, DART, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Services
• Peer Reviewed:
  False
• Source Full Name:
  International Journal of Psychophysiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:79aa638ccda769a06c55de77a0f12f7f3b64e11d04f9e2039a2e00b23bb940e2ae14a584d5a40d268f97b8d451ea6ad88ddd32b2091bc0e68735a81aa0cafed7
• Download URL:
  https://stacks.cdc.gov/view/cdc/192615/cdc_192615_DS1.pdf
• File Type:
  [PDF - 361.24 KB ]