Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter

Details

• Personal Author:
  Antonini JM ; Erdely A ; Hulderman T ; Liston A ; Salmen-Muniz R ; Simeonova PP ; Zeidler-Erdely PC
• Description:
  Welding results in a unique and complex occupational exposure. Recent epidemiological studies have shown an increased risk of cardiovascular disease following welding fume exposure. In this study, we compared the induction of pulmonary and systemic inflammation following exposure to multiple types of welding fumes. Mice were exposed to 340mcg of manual metal arc stainless steel (MMA-SS), gas metal arc-SS (GMA-SS) or GMA-mild steel (GMA-MS) by pharyngeal aspiration. Mice were sacrificed at 4 and 24h post-exposure to evaluate various parameters of pulmonary and systemic inflammation. Alterations in pulmonary gene expression by a custom designed TaqMan array showed minimal differences between the fumes at 4h. Conversely at 24h, gene expression changes were further increased by SS but not GMA-MS exposure. These findings were associated with the surrogate marker of systemic inflammation, liver acute phase gene induction. Interestingly, stress response genes in cardiovascular tissues were only increased following MMA-SS exposure. These effects were related to the initial level of pulmonary cytotoxicity, as measured by lactate dehydrogenase activity, which was greatest following MMA-SS exposure. In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Biomarkers Cardiovascular System Cytotoxins Genetics Immune System Laboratories Lung Lung Diseases Metals Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Animal-studies Aorta Author Keywords: Systemic Inflammation Biological-effects Bronchoalveolar Lavage Cardiopulmonary-function Cardiovascular Cardiovascular-function Cell-alteration Cytotoxic-effects Cytotoxicity Dose-response Fumes Gene-mutation Gene Expression Genes Immune-reaction Laboratory-animals Lung-disorders Lung-function Metal-fumes Particulates Proteins Pulmonary-function Pulmonary-system-disorders Quantitative-analysis Respiratory-system-disorders Serum Proteins Stainless-steel

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• ISSN:
  0300-483X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  153-159
• Volume:
  7
• Issue:
  1
• NIOSHTIC Number:
  nn:20039071
• Citation:
  Toxicology 2011 Sep; 7(1-3):153-159
• Contact Point Address:
  Aaron Erdely, NIOSH/HELD/PPRB, 1095 Willowdale Road, MS-2015, Morgantown, WV 26505-2888, USA
• Email:
  efi4@cdc.gov
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:64861a355622767fe89b672a52d22544b5db9ee0fdab862f27e706328f6ad262af8a3706f64834547df1a29f74eecab00728c7a16551ff6af9337959e8ed6b17
• Download URL:
  https://stacks.cdc.gov/view/cdc/192559/cdc_192559_DS1.pdf
• File Type:
  [PDF - 593.85 KB ]