Efficacy of predictive modeling as a scientific criterion in dermal hazard identification for assignment of skin notations

Details

• Personal Author:
  Ahlers HW ; Chang W-C ; Chen C-P ; Dotson, G. Scott ; Gadagbui B ; Lin Y-C ; Maier A
• Description:
  Skin notations (SNs) represent a hazard characterization tool for alerting workers of health hazards associated with dermal contact with chemicals. This study evaluated the efficacy of a predictive model utilized by the National Institute for Occupational Safety and Health to identify dermal hazards based on potential of systemic absorption compared to hazard assignments based on dermal lethal dose 50% or logarithm of octanol-water partition coefficient. A total of 480 chemicals assigned an SN from at least one of seven institutes were selected and partitioned into seven hazard categories by frequency of SN assignment to provide a basis of evaluation for the predictivity of the examined criteria. We find that all three properties serve as a qualitative indicator in support of a dichotomous decision on dermal hazard; the predictive modeling was identified from a multiple regression analysis as the most significant indicator. The model generated estimates that corresponded to anticipated hazard potentials, suggesting a role of the model to further serve as a hazard-ranking tool. The hazard-ranking capability of the model was consistent with the scheme of acute toxicity classification in the Globally Harmonized System of Classification and Labeling of Chemicals. [Description provided by NIOSH]
• Subjects:
  Biological Factors Chemistry Dermatitis Environmental Monitoring Hazardous Substances Hypersensitivity Immune System Occupational Health Risk Assessment Risk Factors Safety Skin Skin Absorption Skin Diseases Toxicology

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• Keywords:
  Author Keywords: Occupational Skin Exposure Biohazards Biological-effects Biological-factors Chemical-hypersensitivity Chemical-properties Dermal-absorption Dermal-exposure Dermal Lethal Dose 50% Exposure-assessment Exposure-levels Globally Harmonized System Of Classification And Labeling Of Chemicals Hazard Characterization Hazard Ranking Immune-reaction Immunology Mathematical-models Occupational-dermatitis Octanol-water Partition Coefficient Predictive Modeling Qualitative-analysis Risk-analysis Risk-factors Skin-absorption Skin-disorders Skin-exposure Skin-infections Skin-irritants Skin-sensitivity Skin Notation Toxic-effects Toxins

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• ISSN:
  0273-2300
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  NPPTL - National Personal Protective Technology Laboratory ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  63-72
• Volume:
  61
• Issue:
  1
• NIOSHTIC Number:
  nn:20039047
• Citation:
  Regul Toxicol Pharmacol 2011 Oct; 61(1):63-72
• Contact Point Address:
  Chen-Peng Chen, China Medical University, Department of Occupational Safety and Health, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan
• Email:
  chencp@mail.cmu.edu.tw
• Federal Fiscal Year:
  2012
• Peer Reviewed:
  True
• Source Full Name:
  Regulatory Toxicology and Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2db9cb135370a8df92ccd6607b559f39ddadd9a8f5862fa3f64f7644e0420344260bde9a1f8184ce9cc3c07d9e6be13cbac1982497c7bf060a1299f80f47b4ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/192539/cdc_192539_DS1.pdf
• File Type:
  [PDF - 375.76 KB ]