Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

Castranova, Vincent; Lu Y; Luanpitpong S; Pongrakhananon V; Rojanasakul Y; Tse W; Wang L

i

Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells

Public Domain

2011/07/13
By Castranova, Vincent ; Lu Y ; Luanpitpong S ; ...

Details

Personal Author:

Castranova, Vincent ; Lu Y ; Luanpitpong S ; Pongrakhananon V ; Rojanasakul Y ; Tse W ; Wang L
Description:

Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process. [Description provided by NIOSH]
Subjects:

Carcinogens Laboratories Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Respiratory System Safety
Keywords:

Carcinogenicity Cell-alteration Cell-damage Cellular-reactions Chronic-exposure Laboratory-animals Lung-cells Lung-disorders Malignancy Nanotechnology Nanotubes Tumorigenesis
ISSN:

1530-6984
Document Type:

Text
Genre:

Journal Article
Place as Subject:

OSHA Region 3 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Volume:

11
Issue:

7
NIOSHTIC Number:

nn:20038986
Citation:

Nano Lett 2011 Jul; 11(7):2796-2803
Contact Point Address:

Yon Rojanasakul, Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, 26505, USA
Email:

yrojan@hsc.wvu.edu
CAS Registry Number:

Carbon (CAS RN 7440-44-0)
Federal Fiscal Year:

2011
NORA Priority Area:

Manufacturing
Peer Reviewed:

True
Source Full Name:

Nano Letters
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:693f59f703dfad60eb7d19988d24b74920b9b2729b9608fa0e049b3493923a236fedc3b406e907e9c3ca367a3bcc492adc9c4a60e478b41353f6129301ae5549
Download URL:

https://stacks.cdc.gov/view/cdc/192492/cdc_192492_DS1.pdf
File Type:

[PDF - 3.97 MB ]

ON THIS PAGE

Details

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.