The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the National Health and Nutrition Examination Survey 1999-2002

Details

• Personal Author:
  Feng, H. Amy ; Krieg EF Jr.
• Description:
  The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the National Health and Nutrition Examination Survey 1999-2002. The blood lead levels of the women ranged from 0.2 to 17.0 mu g/dL. The estimated geometric mean was 1.4 mu g/dL, and the estimated arithmetic mean was 1.6 mu g/dL. As the blood lead level increased, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of luteinizing hormone increased as blood lead level increased in postmenopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 0.9 mu g/dL for follicle stimulating hormone and 3.2 mu g/dL for luteinizing hormone. Lead may act directly or indirectly at ovarian and non-ovarian sites to increase the concentrations of follicle stimulating hormone and luteinizing hormone. [Description provided by NIOSH]
• Subjects:
  Age Factors Endocrine System Hematologic Tests Lead Occupational Health Safety Urogenital System Women
• Keywords:
  Age-factors Analytical-processes Blood-analysis Blood-serum Hormone-activity Hormones Lead-absorption Mathematical-models Reproduction Reproductive-effects Reproductive-system

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• ISSN:
  0890-6238
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  277-285
• Volume:
  32
• Issue:
  3
• NIOSHTIC Number:
  nn:20038967
• Citation:
  Reprod Toxicol 2011 Nov; 32(3):277-285
• Contact Point Address:
  Edward F. Krieg Jr., National Institute for Occupational Safety and Health, DART, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
• Federal Fiscal Year:
  2012
• Peer Reviewed:
  True
• Source Full Name:
  Reproductive Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0c2410a4f547b025d3a4b5fcb16cd6bdeb08fce57075fe6c4327885dfa9804d1be06a03796ae1b7be389d5ed212e40f1212961ee1d8cd885f067f553bd5e4a9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/192479/cdc_192479_DS1.pdf
• File Type:
  [PDF - 323.93 KB ]