The Relationships Between Blood Lead Levels and Serum Follicle Stimulating Hormone and Luteinizing Hormone in the Third National Health and Nutrition Examination Survey

Details

• Personal Author:
  Krieg EF Jr.
• Description:
  The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31:1 mg/dl. The estimated geometric mean was 2:2 mg/dl, and the estimated arithmetic mean was 2:8 mg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1:7 mg/dl for follicle stimulating hormone and 2:8 mg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries. [Description provided by NIOSH]
• Subjects:
  Age Factors Endocrine System Hematologic Tests Lead Occupational Health Safety Urogenital System Women
• Keywords:
  Age-factors Analytical-processes Blood-analysis Blood-serum Hormone-activity Hormones Lead-absorption Reproduction Reproductive-effects Reproductive-system
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  374-382
• Volume:
  104
• Issue:
  3
• NIOSHTIC Number:
  nn:20032324
• Citation:
  Environ Res 2007 Jul; 104(3):374-382
• Contact Point Address:
  EF Krieg Jr, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
• Email:
  erk3@cdc.gov
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f5a1757a73fcd4d6d3b45aa1c70aa73fdcdf96dd7e7163533de6f4485d22ca0e552d66abac11b355fc4a75680e81381db66dc4a0d8575a49a6b9108752bd8431
• Download URL:
  https://stacks.cdc.gov/view/cdc/186345/cdc_186345_DS1.pdf
• File Type:
  [PDF - 247.01 KB ]