Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments

Details

• Personal Author:
  Chen BT ; Frazer DG ; Lebouf RF ; Stefaniak, Aleksandr B. ; Virji, M. Abbas
• Description:
  Measurement of the surface area of airborne nanoparticles as administered to an experimental subject is critical for characterizing exposures during inhalation experiments. A filter-based surface area measurement methodology is described herein that allows for such determinations. Krypton gas adsorption was used to determine total particle surface area. Track-etched polycarbonate 0.4 µm pore filters were chosen as the collection substrate for metal oxide particles due to their highly reproducible surface areas and low background weights. The subject nanomaterials included two different batches of ultrafine TiO(2), TiO(2) nanorods, and SiO(2). The instrument detection limit for surface area was 200 cm(2) (0.02 m(2)). Ninety percent confidence interval estimates of method accuracy were 17.7-23.5% with a point estimate of 20.8%. The filter-based surface area measurement strategy is demonstrated to be a viable sampling and analysis methodology that provides much needed physical characterization information of particles as administered in an animal inhalation chamber. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Chemistry Chemistry, Analytic Environmental Monitoring Hazardous Substances Inhalation Exposure Laboratories Metals Occupational Health Particulate Matter Respiratory System Safety Silicon Compounds Toxicology

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• Keywords:
  Air-sampling-techniques Airborne-particles Analytical-chemistry Analytical-methods Author Keywords: Nanoparticles Dioxides Exposure-assessment Gas-adsorption Gas-filters Inhalants Inhalation-studies Laboratory-testing Measurement-equipment Metal-oxides Nanotechnology Physical-properties Sampling Sampling-equipment Sampling-methods Sampling Methodology Silicon-compounds Surface-properties Surface Area Toxic-materials Ultrafine Titanium Dioxide

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  4
• NIOSHTIC Number:
  nn:20038707
• Citation:
  Nanotoxicology 2011 Dec; 5(4):687-699
• Contact Point Address:
  Ryan F. LeBouf, PhD, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  rlebouf@cdc.gov
• CAS Registry Number:
  Krypton (CAS RN 7439-90-9) ; Silica (CAS RN 7631-86-9) ; Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:98e0574c914e93ff4360bcef7b7bb62b4a35f58091669654ead24c09031982601fa3f02c09375cbe036042cdc2776c3b2ed80c654d45e21621b887c440c7b9f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/192326/cdc_192326_DS1.pdf
• File Type:
  [PDF - 615.38 KB ]