Nanoindentation measurement of articular cartilage from an in vivo loading model

Details

• Personal Author:
  King KB ; Li C ; Pruitt LA
• Description:
  Repetitive and forceful hand tasks can give rise to joint pain and induce upper musculoskeletal diseases. Measuring the effects of loading on the mechanical properties of cartilage helps relate exposure to outcome, as well as improve assessment and intervention of disease. Recent efforts have used nanoindentation to measure the local mechanical properties of cartilage in small models such as the rabbit metacarpophalangeal joint (MCP). However, there are challenges to interpreting the measured data, as standardized testing protocols and analysis methods for soft tissue nanoindentation are yet to be established. This work presents an alternative measurement method using nanoindentation, and compares it to the conventional Oliver-Pharr method (O-P) for evaluating the elastic modulus of articular cartilage from an in vivo joint flexion model. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Environmental Monitoring Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Cumulative-trauma-disorders Exposure-assessment Laboratory-animals Muscles Musculoskeletal-system-disorders Nanotechnology Repetitive-work
• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  California ; Colorado ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• NIOSHTIC Number:
  nn:20038603
• Citation:
  Trans Annu Meet Orthop Res Soc 2008 Mar; 54:0649
• Email:
  cli@newton.berkeley.edu
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9b4d401b41436b0a0ed0833c130310d2925f983b30729d1f9cf9e8e6032e07f14d02b88b68dc77e2b6bcc820892510802c3bb7d13b359e9e9673af36c31a347b
• Download URL:
  https://stacks.cdc.gov/view/cdc/192255/cdc_192255_DS1.pdf
• File Type:
  [PDF - 220.73 KB ]