Analysis of force-displacement curves of cartilage and biomaterials

Details

• Personal Author:
  Ebenstein DM ; King KB ; Li C ; Lin J ; Pruitt LP
• Description:
  Nano-mechanical testing equipments have made probing small volumes of sample possible, allowing measurement of local mechanical behavior of complex tissues such as articular cartilage. However, current techniques and theories developed for traditional engineering materials are insufficient for analyzing complex soft biomaterials. A few studies have shown significant adhesive effects in the load-displacement data of compliant polymers such as poly(dimethyl siloxane) (PDMS) using the Johnson-Kendall-Roberts (JKR) adhesion model. It is suspected that indentation of hydrated tissues might have similar adhesive effects. However, no study has addressed this. In this study, an improved measurement protocol is discussed for determining the nano-mechanical properties of cartilage tissues; the issues of adhesion and surface-find are addressed in calculating reliable values of the local tissue modulus which are necessary to study the mechanical function of musculoskeletal tissues. Force-displacement curves of PDMS, agarose gel, and articular cartilage are compared. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Biomechanics Cumulative-trauma Cumulative-trauma-disorders Laboratory-animals Muscles Musculoskeletal-system-disorders Nanotechnology Repetitive-work
• ISSN:
  0149-6433
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  California ; Colorado ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• NIOSHTIC Number:
  nn:20038589
• Citation:
  Trans Annu Meet Orthop Res Soc 2007 Feb; 53:1565
• Email:
  limeow@gmail.com
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  University of California - San Francisco
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  Transactions of the Annual Meeting of the Orthopaedic Research Society
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:345cd64e77afee82d5e62f678bd1baf3eb91df741dc5f3cd1c69e321f808bd999e07bc9cb3aefbcc35d8717e9a333577c4904f3545182cde5bc56d1e13977bab
• Download URL:
  https://stacks.cdc.gov/view/cdc/192242/cdc_192242_DS1.pdf
• File Type:
  [PDF - 491.23 KB ]