Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years

Details

• Personal Author:
  Baird DD ; Herring AH ; Hoberman S ; Kesner JS ; Meadows JW ; Stanczyk FZ ; Steiner AZ
• Description:
  OBJECTIVE: To generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging. METHODS: Women aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months provided early-follicular phase serum and urine (N=100). Subsequently, these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. Serum was analyzed for estradiol, follicle-stimulating hormone (FSH), antimullerian hormone, and inhibin B. Urine was analyzed for FSH and estrone 3-glucuronide. Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios. RESULTS: Sixty-three percent of participants conceived within 6 months. After adjusting for age, 18 women (18%) with serum antimullerian hormone levels of 0.7 ng/mL or less had significantly reduced fecundability given intercourse on a fertile day compared with women with higher antimullerian hormone levels (fecundability ratio 0.38; 95% confidence interval [CI] 0.08-0.91). The day-specific fecundability for women with early-follicular phase serum FSH values greater than 10 milli-international units/mL compared with women with lower FSH levels was also reduced, although nonsignificantly (11% of women affected; fecundability ratio 0.44; 95% CI 0.08-1.10). The association with urinary FSH was weaker (27% women affected; fecundability ratio 0.61; 95% CI 0.26-1.26), and the associations for the other markers were weaker still. CONCLUSION: Early-follicular phase antimullerian hormone appears to be associated with natural fertility in the general population. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Cytology Health Care Facilities Workforce And Services Occupational Health Pregnancy Safety Urogenital Diseases Urogenital System
• Keywords:
  Age-factors Age-groups Biological-systems Cell-biology Medical-monitoring Medical-screening Reproductive-system Reproductive-system-disorders Statistical-analysis
• ISSN:
  0029-7844
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  117
• Issue:
  4
• NIOSHTIC Number:
  nn:20038573
• Citation:
  Obstet Gynecol 2011 Apr; 117(4):798-804
• Contact Point Address:
  Anne Z. Steiner, MD, MPH, University of North Carolina, CB #7570, 4001 Old Clinic Building, Chapel Hill, NC 27599
• Email:
  asteiner@med.unc.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Obstetrics and Gynecology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9701724c79c731c2b7d653e5d3aa6f63d360ef581b7e878f019ca3c2a02241ffee6c3fd23e5ba0589c140a62f4f32f9b4346b56471711e2a2422c5ba21895123
• Download URL:
  https://stacks.cdc.gov/view/cdc/192227/cdc_192227_DS1.pdf
• File Type:
  [PDF - 212.65 KB ]