Reduction in surface contamination with antineoplastic drugs in 22 hospital pharmacies in the US following implementation of a closed-system drug transfer device

Details

• Personal Author:
  Connor, Thomas H. ; Jorgenson JA ; Sessink PJM ; Tyler TG
• Description:
  Purpose. Surface contamination with the antineoplastic drugs cyclophosphamide, ifosfamide, and 5-fluorouracil was compared in 22 US hospital pharmacies following preparation with standard drug preparation techniques or the PhaSeal closed-system drug transfer device (CSTD). Methods. Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils, floors in front of BSCs, and counters and analyzed for contamination with cyclophosphamide, ifosfamide, and 5-fluorouracil. Contamination was reassessed several months after the implementation of the CSTD. Surface contamination (ng/cm2) was compared between the two techniques and evaluated with the Signed Rank Test. Results. Using the CSTD compared to the standard preparation techniques, a significant reduction in levels of contamination was observed for all drugs (cyclophosphamide: p < 0.0001; ifosfamide: p < 0.001; 5-fluorouracil: p < 0.01). Median values for surface contamination with cyclophosphamide, ifosfamide, and 5-fluorouracil were reduced by 95%, 90%, and 65%, respectively. Conclusions. Use of the CSTD significantly reduces surface contamination when preparing cyclophosphamide, ifosfamide, and 5-fluorouracil as compared to standard drug preparation techniques. [Description provided by NIOSH]
• Subjects:
  Antineoplastic Agents Biopharmaceutics Drug Therapy Health Care Facilities Workforce And Services Health Personnel Occupational Health Safety
• Keywords:
  Antineoplastic-agents Author Keywords: Antineoplastic Agents Closed-system Drug Transfer Device Cyclophosphamide Drug-therapy Drug Preparation Drugs Health-care Health-care-facilities Health-care-personnel Hospital Pharmacies Medicinal-chemicals Pharmaceuticals Surface Contamination

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• ISSN:
  1078-1552
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Indiana ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-48
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:20038532
• Citation:
  J Oncol Pharm Pract 2011 Mar; 17(1):39-48
• Contact Point Address:
  Dr. Paul J.M. Sessink, Exposure Control B.V., P.O. Box 467, NL-6600AL Wijchen, The Netherlands
• Email:
  info@exposurecontrol.nl
• CAS Registry Number:
  5-Fluorouracil (CAS RN 51-21-8) ; Cyclophosphamide (CAS RN 50-18-0) ; Ifosfamide (CAS RN 3778-73-2)
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Oncology Pharmacy Practice
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:af0c8d6d7913e32217e418ae37c2a4eb6de7f6b3b05a903ff82232d548b39c4abc8a06ef7d674c1dabb2866d82f1cb2534a990369999425ca3bb6b344037ba5d
• Download URL:
  https://stacks.cdc.gov/view/cdc/192210/cdc_192210_DS1.pdf
• File Type:
  [PDF - 146.86 KB ]