Tissue binding affects the kinetics of theophylline diffusion through the stratum corneum barrier layer of skin

Details

• Personal Author:
  Barbero AM ; Frasch, H. Fredrick ; Hettick JM ; Nitsche JM ; Verkhratsky A
• Description:
  New data sets on both (i) equilibrium theophylline (TH) partitioning/binding in stratum corneum and (ii) transient TH diffusion through human epidermis are explained by an extended partition-diffusion model with reversible binding. Data conform to a linear binding isotherm within the tested concentration range (0-2000 :g/mL) with an equilibrium ratio of bound-to-free solute of approximately 1.4. The permeability coefficient for TH is 4.86 × 10-5 cm/h, and the lag time is 20.1 h. Binding occurs as a slow process, significantly affecting the kinetics of dermal penetration. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Transdermal Cell-function Cellular-transport-mechanism Dermatology Exposure-assessment Keratin Kinetics Lag Time Passive Diffusion/Transport Permeable Corneocytes Protein Binding Reversible Binding Skin-absorption Skin-exposure Theophylline Transient Diffusion

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• ISSN:
  0022-3549
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  100
• Issue:
  7
• NIOSHTIC Number:
  nn:20038366
• Citation:
  J Pharm Sci 2011 Jul; 100(7):2989-2995
• Contact Point Address:
  H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Pharmaceutical Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2d2f32990ffc7134f5d9dee59d96279bfafacd61f4b7e0c82da25345554439e7fc63e8a0357eafe8f35553256219c488f8d04ae950bf52c1f4bd1ab09e8325f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/192097/cdc_192097_DS1.pdf
• File Type:
  [PDF - 136.73 KB ]