A two-phase analysis of solute partitioning into the stratum corneum

Details

• Personal Author:
  Kasting GB ; Nitsche JM ; Wang TF
• Description:
  An analysis is presented of partition coefficients KSC/w describing solute distribution into fully hydrated stratum corneum (SC) from dilute aqueous solution (w). A comprehensive database is compiled from the experimental literature covering more than eight decades in the octanol/water partition coefficient Ko/w. It is analyzed according to a two-phase model following that of Anderson, Raykar, and coworkers (1988, 1989), which accounts for uptake by intercellular lipid and corneocyte (keratin plus water) phases having inherently different lipophilicities, as characterized by an SC lipid/water partition coefficient Klip/w and a partition coefficient PCpro/w quantifying cornoeocyte-phase binding. Regression of 72 data points yields useful best-fit recalibrations of power laws (or linear free energy relationships) giving Klip/w and PCpro/w as functions of Ko/w. The specific conclusions of the analysis are as follows: (i) The two-phase model offers substantial improvements over previously proposed analytical representations of KSC/w, yielding an rms error in log10KSC/w of 0.30 limited by the scatter in the data. (ii) The best-fit description of the lipid phase is given by the power law Klip/w=0.43 (Ko/w)0.81, suggesting about half the absolute value of Klip/w relative to previous estimates. (iii) The best-fit description of corneocyte-phase binding differs negligibly from the correlation found by Anderson, Raykar, and coworkers for the more limited set of compounds studied by them. Explicit consideration of the two-phase nature of the SC also furnishes a rational basis for predicting the effects of varying hydration state upon KSC/w. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Stratum Corneum (SC) Binding Cell-function Cellular-transport-mechanism Corneocyte Dermatology Exposure-assessment Exposure-limits Hydration Intercellular Lipid Keratin Protein Microstructure Partition Coefficient Skin-absorption Skin-exposure

  More +
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  95
• Issue:
  3
• NIOSHTIC Number:
  nn:20038219
• Citation:
  J Pharm Sci 2006 Mar; 95(3):649-666
• Contact Point Address:
  Johannes M. Nitsche, Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260-4200
• Email:
  nitsche@eng.buffalo.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ccc1b8b605d75b026d5f8a1141bfd5f57d9ef500d95981b29e8a95777ddd194c1f72bcb075c34f1b40d2cdfa8c72d42d4ee5d0fd2a49e546ceafeff0a0e7306e
• Download URL:
  https://stacks.cdc.gov/view/cdc/191993/cdc_191993_DS1.pdf
• File Type:
  [PDF - 281.28 KB ]