Monte Carlo analysis of impact of underascertainment of mesothelioma cases on underestimation of risk

Details

• Personal Author:
  Bateson TF ; Kopylev L ; Sullivan, Patricia A. ; Vinikoor LC
• Description:
  The accuracy of cancer mortality data varies across different cancers. Mortality records and death certificates may not always reflect the true cause of death for various reasons (e.g., misdiagnosis, improper recording on the death certificate, miscoding of the cause of death recorded on the death certificate). Mesothelioma, a rare tumor which is caused by exposure to asbestos, is a special case. Until 1999 when the 10th revision of the International Classification of Diseases (ICD-10) introduced a specific mesothelioma code, mesotheliom deaths were coded to other causes (e.g., cancer of the pleura, cancer of other or ill-specified sites). Even after the introduction of this mesothelioma code, researchers have shown that estimates of mesothelioma mortality based on death certificates are still biased downward. This article reviews available literature with quantitative information on mesothelioma underascertainment, in particular on different rates of underestimation for pleural and peritoneal mesotheliomas, and suggests two approaches to estimating downward bias in absolute risk estimates due to mesothelioma underascertainment. The choice of approach used depends on whether the information on the proportion of peritoneal mesotheliomas is available. Both approaches are demonstrated and evaluated using a cohort of asbestos workers from Libby, Montana. the methods developed in this article may be used in analyses of other asbestos cohorts and in methodologies to predict future mesothelioma burden in populations. Similar approaches can be used to assess the impact of underascertainment of other cancers on risk estimates of other chemicals. [Description provided by NIOSH]
• Subjects:
  Asbestos Inorganic Chemicals Lung Lung Diseases Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Safety

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• Keywords:
  Asbestos Asbestos-workers Author Keywords: Pleural Mesothelioma Cancer Cancer-rates Death Certificates ICD Codes Libby Worker Cohort Lung-cancer Lung-disease Mesothelial-cells Mortality-data Mortality-rates Peritoneal Mesothelioma Pleural-cavity Pulmonary-cancer Respiratory-neoplasms Respiratory-system-disorders Risk-analysis

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• ISSN:
  1874-2971
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  45-53
• Volume:
  4
• NIOSHTIC Number:
  nn:20038326
• Citation:
  Open Epidemiol J 2011 Jan; 4:45-53
• Contact Point Address:
  Leonid Kopylev, National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 1200 Pennsylvania Ave. NW, MC 8623P, Washington, DC 20460
• Email:
  kopylev.leonid@epa.gov
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  The Open Epidemiology Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2a646f1af9d1c5f4c8cf3acc6114b88d2de6ff84b2b8097bd5265f686c8e17c4eefb7ca66325d4f0485ea3a7997c6cff9c318cbb81d566afccf4389566570a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/192069/cdc_192069_DS1.pdf
• File Type:
  [PDF - 216.53 KB ]