Fenton activity and cytotoxicity studies of iron-loaded carbon particles

Details

• Personal Author:
  Dutta PK ; Nagy A ; Peebles B ; Waldman WJ
• Description:
  The chemical and biological properties of iron-loaded manufactured carbon nanoparticles (Flammruss 101) were contrasted with those of an iron-loaded synthetic carbon particle. X-ray photoelectron spectroscopy was used to characterize the iron on the carbon particles. Production of hydroxyl free radicals via the Fenton reaction was monitored by electron paramagnetic resonance spectroscopy. The iron-loaded synthetic carbon particles produced a positive Fenton response, whereas the iron-loaded manufactured carbon particles did not. The source of the Fenton activity of the synthetic carbon particles is proposed to be a soluble iron compound that was formed during the synthesis of the particle. A likely candidate for the soluble iron species is Fe2F5, which was synthesized and its properties were examined. Higher toxicity of Fe2F5 toward murine macrophages compared with other simple iron salts was attributed to soluble iron that was stabilized by the fluoride ligand. The cytotoxicity of manufactured carbon particles toward murine macrophages decreased or remained unaltered upon impregnation with iron compounds. [Description provided by NIOSH]
• Subjects:
  Aerosols Biological Products Chemistry Cytotoxins Ferrous Compounds Occupational Health Particulate Matter Safety Spectrum Analysis
• Keywords:
  Aerosol-particles Biological-effects Biological-material Carbonates Chemical-properties Chemical-synthesis Cytotoxic-effects Fluorescence-spectrometry Iron-compounds Nanotechnology Particulates Photochemical-reactions Spectrographic-analysis

  More +
• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  44
• Issue:
  17
• NIOSHTIC Number:
  nn:20038097
• Citation:
  Environ Sci Technol 2010 Sep; 44(17):6887-6892
• Contact Point Address:
  Prabir K. Dutta, Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210
• Email:
  dutta.1@osu.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  The Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20060801
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:86d2b6e9d605b394e7840a04da61ccdc4151641c719699b2c377a5cec7e46868f1db8dd3f31f5b5f73cbd3048a9ce0f1d3768c9c38a09f6f9d1b1ac3ea8922f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/191913/cdc_191913_DS1.pdf
• File Type:
  [PDF - 1.05 MB ]