Association of blood lead and tibia lead with blood pressure and hypertension in a community sample of older adults

Details

• Personal Author:
  Bandeen-Roche K ; Glass TA ; Martin D ; Schwartz BS ; Shi W ; Todd AC
• Description:
  Few studies have compared associations of blood lead and tibia lead with blood pressure and hypertension, and associations have differed in samples with occupational exposure compared with those with mainly environmental lead exposure. African Americans have been underrepresented in prior studies. The authors performed a cross-sectional analysis of 2001-2002 data from a community-based cohort in Baltimore, Maryland, of 964 men and women aged 50-70 years (40% African American, 55% White, 5% other race/ethnicity) to evaluate associations of blood lead and tibia lead with systolic and diastolic blood pressure and hypertension while adjusting for a large set of potential confounding variables. Blood lead was a strong and consistent predictor of both systolic and diastolic blood pressure in models adjusted and not adjusted for race/ethnicity and socioeconomic status. Tibia lead was associated with hypertension status before adjustment for race/ethnicity and socioeconomic status (p = 0.01); after such adjustment, the association was borderline significant (p = 0.09). Propensity score analysis suggested that standard regression analysis may have exaggerated the attenuation. These findings are discussed in the context of complex causal pathways. The data suggest that lead has an acute effect on blood pressure via recent dose and a chronic effect on hypertension risk via cumulative dose. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Biomarkers Blood Cardiovascular Diseases Cardiovascular System Demography Epidemiology Hematologic Diseases Lead Men Occupational Health Race Factors Safety Women

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• Keywords:
  Age-factors Age-groups Author Keywords: Blood Pressure Blood-disorders Blood-poisoning Blood-pressure Body Burden Demographic-characteristics Emission Exposure-levels Fluorescence Humans Hypertension Lead Lead-absorption Lead-compounds Racial-factors Social Class Statistical-analysis Tibia X-ray Spectrometry

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  467-478
• Volume:
  163
• Issue:
  5
• NIOSHTIC Number:
  nn:20037668
• Citation:
  Am J Epidemiol 2006 Mar; 163(5):467-478
• Contact Point Address:
  Dr. Brian S. Schwartz, Division of Occupational and Environmental Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7041, Baltimore, MD 21205
• Email:
  bschwart@jhsph.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2006
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:34205663206cca256d78c79d053016f392577a5f69ddfb703e22e3b1d19b8783740cee3eef9b08e9978748e6d5f8e5cabbdc7849f4ecbed030c304b2b856faad
• Download URL:
  https://stacks.cdc.gov/view/cdc/191666/cdc_191666_DS1.pdf
• File Type:
  [PDF - 263.38 KB ]