Environmental Arsenic Exposure and Sputum Metalloproteinase Concentrations

Details

• Personal Author:
  Burgess JL ; Clark Lantz R ; Josyula AB ; Kopplin MJ ; Kurzius-Spencer M ; McClellen HE ; Poplin GS ; Sturup S
• Description:
  Exposure to arsenic in drinking water is associated with an increased rate of lung cancer. The objective of this study was to determine whether arsenic exposure at relatively low concentrations ( approximately 20mug/L) is associated with changes in biomarkers of lung inflammation, as measured by the ratio of sputum metalloproteinase and antiproteinase activity. A total of 73 subjects residing in Ajo and Tucson, Arizona were recruited for this cross-sectional study. Tap water and first morning void urine were analyzed for arsenic. Matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in induced sputum. Household tap water arsenic levels in Ajo (20.3+/-3.7mug/L) were higher than in those Tucson (4.0+/-2.3mug/L), as were mean urinary total inorganic arsenic levels (29.1+/-20.4 and 11.0+/-12.0mug/L, respectively). Log-normalized MMP-2, MMP-9, and TIMP-1 concentrations in sputum were not significantly different between towns. However, after adjusting for town, asthma, diabetes, urinary monomethylarsonic acid/inorganic arsenic, and smoking history, total urinary arsenic was negatively associated with MMP-2 and TIMP-1 levels in sputum and positively associated with the ratio of MMP-2/TIMP-1 and MMP-9/TIMP-1 in sputum. Increased sputum proteinase/antiproteinase activity suggests a potential toxic mechanism for low-level arsenic exposure. [Description provided by NIOSH]
• Subjects:
  Arsenic Biomarkers Drinking Water Environmental Exposure Environmental Monitoring Inorganic Chemicals Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Arsenates Arsenic-compounds Arsenites Cancer Drinking-water Environmental-exposure Exposure-assessment Lung-cancer Lung-disorders Lung-irritants
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  283-290
• Volume:
  102
• Issue:
  3
• NIOSHTIC Number:
  nn:20031216
• Citation:
  Environ Res 2006 Nov; 102(3):283-290
• Email:
  jburgess@email.arizona.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of Arizona, Tucson, Arizona
• Peer Reviewed:
  True
• Start Date:
  19950701
• Source Full Name:
  Environmental Research
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8b7e3e17df4aad04f8aec54467d6ea03ed5d9fb29e314527b1a63a022927bfde8a5dfea64ed55d4da9e9a537a301f434c0a9db19cd6cb3c6d7132de9bb6e170b
• Download URL:
  https://stacks.cdc.gov/view/cdc/191529/cdc_191529_DS1.pdf
• File Type:
  [PDF - 204.66 KB ]