Possible Genotoxic Risk in Coal Workers’ Pneumoconiosis

Details

• Personal Author:
  Duydu Y ; Karakaya A ; Ulker OC ; Ustundag A ; Yucesoy, Berran
• Description:
  Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP) which is a chronic inflammatory and fibrotic lung disease. In recent years chronic inflammation is accepted a common important factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and formation of free radicals. Interaction of reactive oxygen species (ROS) with DNA augments the likelihood of DNA structural and transcriptional errors. To investigate the genotoxic risk of occupational exposure to coal dust in CWP patients, sister chromatid exchange (SCE) and micronucleus (MN) tests were performed on CWP patient group (n = 23), coal workers group (n = 29) and unexposed control group (n = 29). Both SCE and MN frequencies in CWP patients were found significantly higher than in coal workers and unexposed group. There were no differences between coal workers and unexposed groups' SCE and MN frequencies. While positive correlations between SCE frequency and the exposure duration time or age were found in coal workers, no correlations were found in other two groups. There was no effect of smoking on the frequencies of SCE and MN in all three groups. Based on these results, it can be suggested that development of CWP related to occupational exposure to coal mine dust leads to a significant induction of cytogenetic damage in peripheral lymphocytes of CWP patients. [Description provided by NIOSH]
• Subjects:
  Coal Coal Mining Dust Free Radicals Lung Lung Diseases Mining Occupational Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Coal-dust Coal-workers Coal-workers-pneumoconiosis Diseases Dust-exposure Dust-particles Dusts Free-radical-generation Free-radicals Genotoxic-effects Genotoxicity Lung-disease Occupational-diseases Occupational-exposure Risk-analysis Risk-factors

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• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  164
• NIOSHTIC Number:
  nn:20031105
• Citation:
  Toxicol Lett 2006 Sep; 164(Suppl 1):S35
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Toxicology Letters
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b71ab035b6907cdbf5b2739e53f8ad385606538e949729d60cf564c90404a8909754aec2c12121e6e832329a71840bd202d7922c4c64ffc2c249c038929c270a
• Download URL:
  https://stacks.cdc.gov/view/cdc/191460/cdc_191460_DS1.pdf
• File Type:
  [PDF - 71.52 KB ]