Considerations in Estimating Social and Economic Impacts of Immunotoxic Agents

Details

• Personal Author:
  Blanciforti LA ; Luster MI
• Description:
  To make appropriate regulatory policy decisions, the potential social and economic impacts of the policy must first be established. For environmental and occupational agents, social and economic impacts are derived from animal toxicology and, when available, human studies that serve as the base for risk-benefit analysis (RBA). Because immune function is associated with resistance to infectious disease, developing RBA for data derived from immunotoxicology studies will require determining the changes in the frequency or severity of infectious disease resulting from an exposure. Fortunately, considerable information is readily available for identifying the frequency of infectious diseases in the general population and its social and economic impacts and to assist the risk assessor when conducting RBA for immunotoxicology endpoints. The following is a brief review describing some issues in using immunotoxicity data when conducting RBA. It presents an economic methodology to determine the economic impacts of infectious diseases to society, sources where these types of information are available, and an example using a specific infectious disease, otitis media. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Hazardous Substances Immune System Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Toxicology
• Keywords:
  Immune-reaction Immune-system-disorders Immunotoxins Infectious-diseases Occupational-exposure Risk-analysis Risk-factors Toxic-effects Toxins
• ISSN:
  1080-7039
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  5
• NIOSHTIC Number:
  nn:20030951
• Citation:
  Hum Ecol Risk Assess 2006 Oct; 12(5):888-903
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Human and Ecological Risk Assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f180b7baf3c3c685b83084025117d15801eb8fd8a7ae69c69f07c3dda99fad468248b04ba2a99a979f6c6a7d31e10242281b63839336a184a6331da41f686dc8
• Download URL:
  https://stacks.cdc.gov/view/cdc/191378/cdc_191378_DS1.pdf
• File Type:
  [PDF - 243.22 KB ]