Safety Evaluation and Risk Assessment Using Immunotoxicology Methods

Details

• Personal Author:
  Dean JH ; Gerberick GF ; Hastings KL ; Hincks J ; Luster MI ; Neumann DA
• Description:
  The field of immunotoxicity has advanced considerably in the past few years with the systematic evaluation of methods to predict immunosuppression, myelosuppression, and certain types of hypersensitivity. International interlaboratory comparisons have been conducted with methods for detecting immunosuppression (White et al., 1994) and contact hypersensitivity with good agreement (Kimber et al., 1995). The standard tier for immunotoxicity assessment, as described by the National Toxicology Program (Luster et al., 1988), and methods suggested by the GECD 407 Guideline (van Loveren et al., 1996) are considered useful in both the mouse and rat. Likewise, these new methods have been introduced and evaluated in the safety assessment of new pharmaceuticals and chemicals by some companies. Most of the methods developed have been drawn from our experience in clinical immunology and an improved understanding of the immune system through advances in molecular biology and basic immunology. There is still work to be done to better document the correlation between animal immunotoxicity results and adverse effects in humans following exposure to chemicals in our environment, and to define predictive methods for evaluating the potential of a drug to induce allergy and autoimmunity, still a significant unpredicted clinical finding. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Immune System Occupational Health Risk Assessment Risk Factors Safety Safety Management Toxicology
• Keywords:
  Immune-reaction Immunodiagnosis Immunology Risk-factors Safety-measures Safety-practices Safety-research Toxic-effects
• ISSN:
  1091-5818
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  277-296
• Volume:
  17
• Issue:
  3
• NIOSHTIC Number:
  nn:20033917
• Citation:
  Int J Toxicol 1998 May-Jun; 17(3):277-296
• Contact Point Address:
  JH Dean, Sanofi Res, Sanofi Pharmaceut Inc, 9 Great Valley Pkwy,POB 3026, Malvern, PA 1935
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a35eebcbaa09276a2d1b624698ef7acde35d343b3f83f6348c9fea098243144decd8f28b288acb1ee88d718119635e1ebc32470a68bca459a504b574fa6148f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/189319/cdc_189319_DS1.pdf
• File Type:
  [PDF - 397.92 KB ]