Effects of Temperature on Vibration-Induced Damage in Nerves and Arteries

Details

• Personal Author:
  Bain JL ; Curry BD ; Govindaraju SR ; Riley, Danny A. ; Bain JL ; Curry BD ; Govindaraju SR ; Riley, Danny A.
• Description:
  Vasospastic episodes in hand-arm vibration syndrome are more prevalent among power-tool workers in cold climates. To test whether cold enhances vibration-induced damage in arteries and nerves, tails of Sprague-Dawley rats were vibrated at room temperature (RT) or with tail cooling (<15 degrees C). Cold vibration resulted in a colder tail than either treatment alone. Vibration at both temperatures reduced arterial lumen size. RT vibration generated more vacuoles in arteries than cold vibration. Vibration and cold induced nitration of tyrosine residues in arteries, suggesting free-radical production. Vibration and cold generated similar percentages of myelinated axons with disrupted myelin. Cold with and without vibration caused intraneural edema and dilation of arterioles and venules with blood stasis, whereas vibration alone did not. The similarities, differences, and interactive effects of cold and vibration on nerve and artery damage indicate that temperature is involved mechanistically in the pathophysiology of hand-arm vibration syndrome. [Description provided by NIOSH]
• Subjects:
  Animals Cold Temperature Free Radicals Laboratories Nervous System Occupational Health Safety Temperature Vibration
• Keywords:
  Animal-studies Cold-environments Free-radicals Laboratory-animals Nerve-damage Nerves Temperature-effects Vibration-effects
• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  415-423
• Volume:
  33
• Issue:
  3
• NIOSHTIC Number:
  nn:20030005
• Citation:
  Muscle Nerve 2006 Mar; 33(3):415-423
• Contact Point Address:
  Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
• Email:
  dariley@mcw.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities ; Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Muscle & Nerve
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19c8dab4db84bf3b63c9b45c17f5f87fe0ddfa3a179deb7fcda1259cc6bfa01f95f62cb8c57cdcee79940af1e4e3ed4768852213711efd579790a1985881e925
• Download URL:
  https://stacks.cdc.gov/view/cdc/190866/cdc_190866_DS1.pdf
• File Type:
  [PDF - 723.75 KB ]