Development of an Animal Model to Study the Potential Neurotoxic Effects Associated with Welding Fume Inhalation

Details

• Personal Author:
  Antonini JM ; Miller DB ; O'Callaghan JP
• Description:
  Serious questions have been raised regarding a possible causal association between neurological effects in welders and the presence of manganese in welding fume. An experimental model is needed that could examine the potential neurotoxic effect of manganese after pulmonary exposure to welding fume. The National Institute for Occupational Safety and Health (NIOSH) has recently finished construction of a completely automated, computer controlled welding fume generation and inhalation exposure system for laboratory animals. The system is comprised of a programmable six-axis robotic welding arm and a water-cooled arc welding torch. A flexible trunk has been attached to the robotic arm of the welder and is used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Preliminary fume characterization studies have indicated that particle morphology, size, and chemical composition were comparable to welding fume generated in the workplace. Animal inhalation studies are currently underway. With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Laboratories Manganese Nervous System Occupational Health Respiratory System Respiratory Tract Diseases Safety Welding
• Keywords:
  Animal-studies Central-nervous-system Exposure-chambers Exposure-levels Fumes Fumigants Inhalation-studies Laboratory-animals Manganese-compounds Models Neurotoxic-effects Neurotoxicity Neurotoxicology Neurotoxins Pulmonary-system-disorders

  More +
• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  5
• NIOSHTIC Number:
  nn:20030881
• Citation:
  Neurotoxicology 2006 Sep; 27(5):745-751
• Contact Point Address:
  Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
• Email:
  jga6@cdc.gov
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:407ac6ebe72a63b0ac9622625d058eceb1005c5d44dddd915a3a445f1ff47b9d67084a346b172188f4c130bbab837ee6ec9e21e0c9755c78f223496fd1870833
• Download URL:
  https://stacks.cdc.gov/view/cdc/191339/cdc_191339_DS1.pdf
• File Type:
  [PDF - 444.22 KB ]