Metabolic Functions of Alveolar Type II Cells in Acute Silicosis

Details

• Personal Author:
  Bowman L ; Ducatman BS ; Hubbs, Ann F. ; Levy RD ; Miles PR ; Singh G ; Vallyathan V
• Description:
  We have examined some metabolic functions of alveolar type II cells during experimental silicosis in rats. Consistent with previous studies, hypertrophied and hyperplastic alveolar type II cells and alveolar lipoproteinosis were observed at two and four weeks after intratracheal administration of 20 mg silica. Both hypertrophied and normal alveolar type II cells from all exposure groups contained immunohistochemically detectable lysozyme and surfactant apoprotein. Cytochrome P450 28 I was immunohistochemically demonstrated in the Clara and normal type II cells of control and silica exposed rat lungs. However, the hypertrophied and hyperplastic alveolar type II cells contained no immunohistochemically detectable cytochrome P450 281. The concentration of P450 281 containing alveolar cells (positive cells/mm2) was unaltered by silica. These findings support the hypothesis that during experimental silicosis, the hypertrophied type II cells are a newly-induced population of alveolar cells metabolically distinct from the pre-existing type II cells. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Environmental Monitoring Hazardous Substances Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Alveolar-cells Exposure-assessment Exposure-levels Exposure-limits Lung-cells Lung-disorders Lung-tissue Pulmonary-system-disorders Respiratory-system-disorders Silica-dusts Silicates Silicosis Toxic-dose Toxic-materials Toxins

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  74
• Volume:
  36
• Issue:
  1
• NIOSHTIC Number:
  nn:20030581
• Citation:
  Toxicologist 1997 Mar; 36(1)(Pt 2):74
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  False
• Part Number:
  2
• Source Full Name:
  The Toxicologist. Society of Toxicology 36th Annual Meeting, March 9-13, 1997, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22d37a611a892c2de0e85bd85e8c53fa142ae5b71c0f37ffc594875de6dba49c6ba14a350a6edb9a9b347167f135060979e55f0b815ef52c4b3808bd96f0696b
• Download URL:
  https://stacks.cdc.gov/view/cdc/191138/cdc_191138_DS1.pdf
• File Type:
  [PDF - 136.11 KB ]