Immunological and Inflammatory Assessments

Details

• Personal Author:
  Biagini, Raymond E. ; Lemiere C ; Zeiss CR
• Description:
  The next sections discuss the different tests that can be performed to make a diagnosis in this patient. This chapter addresses the current methods for performing an immunological assessment by skin testing and by serological assays, and also describes the role of noninvasive assessment of airway inflammation by sputum cell counts. Immunologic assessment of individuals with suspected occupational asthma (OA) by skin testing has been an important tool in the diagnosis of OA, as exemplified by the classic work of Dr. J. Pepys on industrial enzymes in the detergent industry and platinum salts in the refining industry (1,2). A number of recent excellent reviews on OA and on the epidemiology of asthma in the workplace describe the extensive number and diversity of important occupational allergens (3-9). The examples of occupational agents that have been assessed by skin testing and other diagnostic studies are listed in Table I (10-64). Demonstration of skin test reactivity indicates that the worker has become sensitized to low- or high-molecular-weight allergen in the work environment and is not by itself diagnostic of OA as discussed elsewhere in this volume. The immediate wheal and flare reaction induced by prick or intradermal skin tests to occupational allergens is associated with an underlying IgE antibody-mediated response, which can also be confirmed by specific IgE in vitro assays as discussed below. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Hypersensitivity Immune System Occupational Diseases Occupational Exposure Occupational Health Respiratory System Safety Skin Workplace

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• Keywords:
  Airway-obstruction Airway-resistance Allergens Bronchial-asthma Immunological-tests Immunology Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Skin-tests Work-environment Worker-health Workers

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• ISBN:
  9780824729776
• Publisher:
  Taylor & Francis Group
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179-197
• NIOSHTIC Number:
  nn:20030411
• Citation:
  Asthma in the Workplace and Related Conditions, Third Edition. Bernstein IL, Chan-Yeun M, Malo JL, Bernstein DI, eds., New York: Taylor and Francis Group, 2006 Jan; :179-197
• Editor(s):
  Bernstein IL; Chan-Yeung M; Malo JL; Bernstein DI
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  False
• Source Full Name:
  Asthma in the workplace and related conditions, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:927505c42bc8fd918aaaaa31da2664909d2681e87fcee1c34db85b519f18d18013738c1c8986e637769635002128f81926f542b6f781c197c4fd5f53e9edcdcb
• Download URL:
  https://stacks.cdc.gov/view/cdc/191046/cdc_191046_DS1.pdf
• File Type:
  [PDF - 2.04 MB ]