The Genetic and Environmental Factors Involved in Benzidine Metabolism and Bladder Carcinogenesis in Exposed Workers

Details

• Personal Author:
  Carreón T ; LeMasters GK ; Ruder, Avima M. ; Schulte, Paul A.
• Description:
  Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other aromatic amines. Metabolic polymorphisms and bladder cancer in the context of occupational exposure to aromatic amines are also reviewed, and the environmental and genetic relationships of benzidine exposure and genetic susceptibility are outlined. Only a few studies of bladder cancer genetic susceptibility in populations exposed occupationally to arylamines have been published. The results of these case-control studies show conflicting results, reflecting metabolic differences between monoarylamines and diarylamines such as benzidine. Additional studies and pooled analyses of existing data are needed to establish if individuals are at higher risk of bladder cancer given the presence of certain alleles that make them more susceptible to this disease. [Description provided by NIOSH]
• Subjects:
  Carcinogens Case Reports Energy Metabolism Environmental Health Genetics Neoplasms Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System

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• Keywords:
  Arylamines Bladder-cancer Bladder-disease Bladder-disorders Cancer Carcinogenesis Carcinogenicity Case-studies Diseases Environmental-factors Genetic-factors Metabolism Occupational-exposure Risk-analysis Risk-factors Worker-health Workers

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• ISSN:
  1093-9946
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20030269
• Citation:
  Front Biosci 2006 Sep; 11(1):2889-2902
• Email:
  tjc5@cdc.gov
• CAS Registry Number:
  4,4'-Diaminodiphenyl (CAS RN 92-87-5)
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Bioscience
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:149161ef430f53502673424570edb4ca85d88b5f753f6fda275dffecde71fde3878e4ec97d6ff7749bdd7aa48840f84ea28dbe685784850c1b70f0df8c64d413
• Download URL:
  https://stacks.cdc.gov/view/cdc/190989/cdc_190989_DS1.pdf
• File Type:
  [PDF - 123.03 KB ]