Toxicity of Chlorpyrifos and Chlorpyrifos Oxon in a Transgenic Mouse Model of the Human Paraoxonase (PON1) Q192R Polymorphism

Details

• Personal Author:
  Radke, Marilyn S.
• Description:
  The Centers for Disease Control and Prevention (CDC) is required by Congress to oversee Department of Defense lethal chemical warfare agent management and destruction activities to protect public health. Oversight activities include handling, transporting, monitoring, and destroying chemical munitions containing the nerve agents GA (tabun), GB (sarin), VX, and the blister agent HD (sulfur mustard); and medical oversight of workers. In June and July 2003, CDC conducted site visits to the Tooele Chemical Agent Disposal Facility in Tooele, Utah and the Umatilla Chemical Agent Disposal Facility in Hermiston, Oregon, respectively. CDC evaluated the medical clinics and occupational health programs in place to treat potential worker exposures to chemical warfare agents at these stockpiles. Approximately 700 employees at each stockpile are at risk of potential agent exposure, and approximately 300 employees routinely enter toxic environments immediately dangerous to life and health. Findings were based on visits to the clinic facilities, discussions with staff, review of pertinent documents and materials, and observation of a training exercise. Recommendations were made regarding patient decontamination procedures, staff training, clinic accreditation by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), medical surveillance/screening for nerve agent exposure, red blood cell (RBC) cholinesterase monitoring, hazard assessment, development of a heat stress prevention program based on current American Council of Governmental Industrial Hygienists guidelines, use of a sensor system to measure core body temperature, development of a program to evaluate functional capacity of workers using special personal protective equipment in toxic environments, and surveillance of heat-induced health events. [Description provided by NIOSH]
• Subjects:
  Chemical Warfare Agents Hazardous Substances Health Care Facilities Workforce And Services Occupational Exposure Occupational Health Public Health Risk Assessment Risk Factors Safety Staff Development Waste Management

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• Keywords:
  Chemical-warfare-agents Decontamination Employee-health Employees Medical-facilities Occupational-exposure Occupational-health Occupational-health-programs Occupational-safety-programs Public-health Risk-analysis Risk-factors Surveillance-programs Toxic-effects Toxins Waste-disposal Waste-disposal-systems Worker-health Workers

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• Publisher:
  American Public Health Association
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20030123
• Citation:
  APHA 132nd Annual Meeting and Exposition, Washington, DC, November 6-10, 2004. Washington, DC: American Public Health Association, 2004 Nov; :76338
• Contact Point Address:
  Marilyn S. Radke, MD, MPH, FACOEM, Centers for Disease Control and Prevention, NIOSH, CDC, NIOSH, Atlanta Field Office, 1600 Clifton Rd., MS E-06, Atlanta, GA 30333, 404-498-2579
• Email:
  mzr4@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Source Full Name:
  APHA 132nd Annual Meeting of the American Public Health Association, November 6-10, 2004
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:03328ab6c287fc6db67f2c51d5fbe6be4a1e95df1c3cbe2488fa0e2dbb9df37d0350d47033e16de3e0ea407b4fae4a224c9a880e28699c2e355658470c416186
• Download URL:
  https://stacks.cdc.gov/view/cdc/190944/cdc_190944_DS1.pdf
• File Type:
  [PDF - 69.46 KB ]