Acute Vibration Increases alpha(2C)-Adrenegic Smooth Muscle Constriction and Alters Thermosensitivity of Cutaneous Arteries [2005]

Details

• Personal Author:
  Christiani, David C. ; Dai HL ; Hang JQ ; Su L ; Sun BX ; Wang XR ; Zhang HQ ; Zhou W
• Description:
  Occupational exposed to endotoxin in organic dust may induce acute and chronic lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure. Polymorphisms of this gene are associated with altered enzyme activity. We investigated the associations between mEH polymorphisms, endotoxin exposure, and lung function decline in a prospective study of 265 workers exposed to endotoxin and 234 controls. The population was divided into rapid and slow decline groups by the annual decline rate of lung function (FEV1 greater or less than 40 ml) during the 20 year follow up. mEH Tyr113His and His139Arg polymorphisms were genotyped by the 5' nuclease assay (TaqMan). Results were analyzed using multiple logistic regression models, adjusting for relative covariates. A stronger association between endotoxin exposure and rapid lung function decline was found among mEH genotypes associated with lower enzyme activity, with an adjusted odds ratios (AORs) of 1.74 (95% confidence interval, 0.71-4.28), 2.07 (0.99-4.33), and 4.79 (1.31-17.60) for Tyr/Tyr, Tyr/His, and His/His genotype groups, respectively, for the Tyr113His polymorphism; and 2.31 (0.72-7.41) and 2.25 (1.27-3.99) for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that in mEH polymorphisms may modify the association between occupational endotoxin exposure and lung function decline. [Description provided by NIOSH]
• Subjects:
  Dust Endotoxins Enzymes Genetics Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Textile Industry

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• Keywords:
  Genes Lung-disorders Lung-function Models Occupational-exposure Organic-dusts Pulmonary-system-disorders Textile-mills Textile-workers Textiles Worker-health Workers

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• ISSN:
  1546-3222
• Publisher:
  American Thoracic Society
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• NIOSHTIC Number:
  nn:20030117
• Citation:
  Proc Am Thorac Soc 2005 May; 2(Abstracts):A918
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3c96088d9a55e162274ed73a61eda8ad3fa931af2faa8bd8001214d651e168c9112066ff98ef426dc681cdf6147f1fe70d694df3ecc9bb564ec6378f665e359b
• Download URL:
  https://stacks.cdc.gov/view/cdc/190938/cdc_190938_DS1.pdf
• File Type:
  [PDF - 441.52 KB ]