Cotton Dust and Endotoxin Exposure and Long-Term Decline in Lung Function: Results of a Longitudinal Study

Details

• Personal Author:
  Christiani, David C. ; Dai H-L ; Eisen EA ; Olenchock, Stephen A. ; Pothier L ; Ryan LA ; Wegman, David H. ; Ye T-T ; Zhang S
• Description:
  BACKGROUND: To evaluate the relationship between long-term exposure to cotton dust and Gram-negative bacterial endotoxin on lung function, we conducted an 11-year follow-up study of cotton textile workers in Shanghai, China. METHODS: Workers at a nearby silk-thread manufacturing mill were used as a referent population. Ninety percent of the original cohort of 445 cotton and 467 silk textile workers--both active and retired--were identified for testing in the 11th year. Questionnaires and spirometric testing were performed, as well as cotton dust and endotoxin sampling at three points over the 11-year follow-up period: at baseline, at Year 5, and at Year 11. After excluding deaths and subjects on sick-leave, 84% of the original cohort had complete health and environmental data. RESULTS: The data were reanalyzed using generalized estimating equations feedback model which allow for subject transfer over time between work areas, various exposure levels to dust and endotoxin, and FEV1. Cotton workers had a larger loss of FEV1 during the first 5 years of study (-40 mls/yr) as compared with the second 6 years of follow-up (-18 mls/yr). During the same periods, the average decline among silk workers was slightly higher in the first period, but was more consistent (-30 mls/yr vs. -27 mls/yr), and these differences could not be explained by worker selection or dropout. When cumulative exposure to dust and endotoxin were estimated and used in a multivariate model (GEE) for FEV1 loss, cumulative dust, but not endotoxin, was associated with 11-year loss in FEV1 after adjustments for confounders. There was evidence of feedback between dust-exposure levels and FEV1, indicating the existence of a healthy-worker survivor effect. After accounting for a healthy-worker survivor effect, we found a significant relationship between dust exposure and FEV1 decline. CONCLUSIONS: Our results suggest that cotton dust is more strongly associated with chronic airflow limitation than associated endotoxins. Further work is needed to clarify potential reversibility after cessation of exposure, and the relative contributions of dust, endotoxin, and tobacco to chronic respiratory impairment in cotton and other vegetable-exposed workers. [Description provided by NIOSH]
• Subjects:
  Dust Endotoxins Gossypium Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Respiratory Tract Diseases Risk Assessment Risk Factors Safety Surveys And Questionnaires Textile Industry

  More +
• Keywords:
  Author Keywords: Occupation Byssinosis China Chronic Lung Disease Cotton-dust Cotton-mill-workers Cotton Dust Dust-exposure Dusts Occupational-exposure Pulmonary-system-disorders Questionnaires Respiratory-system-disorders Risk-analysis Risk-factors Sampling Textile-workers Textiles-industry Vegetable Dust

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  321-331
• Volume:
  35
• Issue:
  4
• NIOSHTIC Number:
  nn:20029984
• Citation:
  Am J Ind Med 1999 Apr; 35(4):321-331
• Contact Point Address:
  David C. Christiani, Harvard School of Public Health, Building I, Room 1405, 665 Huntington Avenue, Boston, MA 02115
• Federal Fiscal Year:
  1999
• Performing Organization:
  Harvard University
• Peer Reviewed:
  True
• Start Date:
  19870701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24361dbd3a4377bd17d6237ed03371b8d76474e8ed93801729329248a33747cfd510e2b6159dd7079c148b1092fa03811b12e01ece04e0cf58d4aa5f85e9f973
• Download URL:
  https://stacks.cdc.gov/view/cdc/190847/cdc_190847_DS1.pdf
• File Type:
  [PDF - 66.81 KB ]