Genetic Susceptibility to Benzene and Shortened Gestation: Evidence of Gene-Environment Interaction

Details

• Personal Author:
  Chen D ; Christiani, David C. ; Niu T ; Ryan L ; Smith T ; Wang L ; Wang X ; Wang Z ; Xu X ; Zuckerman B ; Chen D ; Christiani, David C. ; Niu T ; Ryan L ; Smith T ; Wang L ; Wang X ; Wang Z ; Xu X ; Zuckerman B
• Description:
  This study investigated whether the association between low level benzene exposure and shortened gestation is modified by two susceptibility genes, CYP1A1 and GSTT1. This report includes 542 (302 nonexposed, 240 benzene-exposed) nonsmoking and nondrinking mothers of singleton live births at Beijing Yanshan Petrochemical Corporation between June 1995 and June 1997. Epidemiologic and clinical data and blood samples were obtained from mothers. Multiple linear regression models were used to estimate the associations of benzene exposure and genetic susceptibility with gestational age, adjusting for maternal age, education, parity, stress, passive smoking, prepregnancy weight and height, and infant's sex. Without consideration of genotype, benzene exposure was associated with a decrease in mean gestational age of 0.29 (standard error (SE), 0.12) week. When stratified by the maternal CYP1A1 genotype, the estimated decrease was 0.54 (SE, 0.12) week for the AA group, which was significantly greater (p = 0.003) than that for the Aa/aa group, which showed no decrease in gestational age. When both CYP1A1 and GSTT1 were considered, the greatest decrease was found among exposed mothers with the CYP1A1 AA-GSTT1 absent group (0.79 (SE, 0.25) week) and the CYP1A1 AA-GSTT1 present group (0.50 (SE, 0.22) week). Among the nonexposed, genetic susceptibility alone did not confer a significant adverse effect. This study provides evidence of gene-environment interaction and supports further assessment of the role of genetic susceptibility in the evaluation of reproductive toxins. [Description provided by NIOSH]
• Subjects:
  Age Factors Benzene Epidemiology Occupational Exposure Occupational Health Pregnancy Risk Assessment Risk Factors Safety Solvents Urogenital Diseases Urogenital System

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• Keywords:
  Age Factors Author Keywords: Benzene Benzenes Cytochrome P-450 CYP1A1 Environmental Exposure Gene Mutation Genes Genetic Disorders Genetic Predisposition To Disease Gestational Age Glutathione Transferase Occupational Exposure Organic Solvents Reproductive Hazards Reproductive System Disorders Risk Factors Statistical Analysis Stress

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  152
• Issue:
  8
• NIOSHTIC Number:
  nn:20029941
• Citation:
  Am J Epidemiol 2000 Oct; 152(8):693-700
• Contact Point Address:
  Dr. Xiaobin Wang, Department of Pediatrics, Maternity 4, Boston University School of Medicine, 818 Harrison Avenue, Boston, MA 02118
• Email:
  xbwang@bu.edu
• CAS Registry Number:
  Ammonia (CAS RN 7664-41-7) ; Benzene (CAS RN 71-43-2) ; Hydrogen sulfide (CAS RN 7783-06-4) ; Manganese (CAS RN 7439-96-5) ; Ammonia (CAS RN 7664-41-7) ; Benzene (CAS RN 71-43-2) ; Hydrogen sulfide (CAS RN 7783-06-4) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Fertility and Pregnancy Abnormalities ; Disease and Injury: Fertility and Pregnancy Abnormalities
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19921201
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  19990131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:86e7b26ec516aaed5eb2e7afa28d0940467d4aa53bb5096d042f8bc1af0e7bf12c5679ab456fb92c0cb28d0abd1a0fce76a41f39471cbbb31178fba740df8fe5
• Download URL:
  https://stacks.cdc.gov/view/cdc/190813/cdc_190813_DS1.pdf
• File Type:
  [PDF - 90.02 KB ]