Regulated Workplace Ketones and Their Interference in the PFBHA Method for Aldehydes

Details

• Personal Author:
  Lin Y-W ; Que Hee SS
• Description:
  Ketones are the major positive interferences for an aldehyde dynamic air sampler that consists of 200-mg 20 percent (w/w) O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) on Tenax TA contained in a Pyrex tube 7-mm OD, 5-mm ID, and 70-mm in length, that utilizes a personal battery-powered pump at 10-50 mL/min. The ketone O-oxime derivatives were synthesized to allow absolute quantitation of O-oximes formed during sampling. Wet spiking allowed ketone recoveries to be found. Ketone vapors of known concentrations were generated statically in Tedlar gas bags. The O-oximes were desorbed with hexane, and an aliquot injected for gas chromatographic analysis on a nonpolar capillary column with mass spectrometric or electron capture detection. Gas phase recoveries up to 200 ppm-hour loadings exceeded 75 percent at 25 degrees C for chloroacetone, cyclohexanone, diacetone alcohol, diethyl ketone, dipropyl ketone, ethyl butyl ketone, methyl amyl ketone, methyl butyl ketone, 2-methylcyclohexanone, methyl ethyl ketone, methyl isobutyl ketone, methyl isopropyl ketone, and methyl propyl ketone. The recoveries for acetophenone, 2-chloroacetophenone, and ethyl amyl ketone were lower than 75 percent, and were caused by steric hindrance. Sampling for both aldehydes and ketones is recommended at 10 mL/min for TLV concentrations. [Description provided by NIOSH]
• Subjects:
  Aldehydes Environmental Monitoring Formaldehyde Mass Spectrometry Occupational Health Safety Workplace
• Keywords:
  Air-sampling Air-sampling-techniques Exposure-limits Gas-chromatography Mass-spectrometry Sampling-methods Workplace-monitoring
• ISSN:
  1047-322X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  11
• NIOSHTIC Number:
  nn:20029848
• Citation:
  Appl Occup Environ Hyg 2000 Nov; 15(11):855-862
• CAS Registry Number:
  Acetaldehyde (CAS RN 75-07-0) ; Chloroacetaldehyde (CAS RN 107-20-0) ; Crotonaldehyde (CAS RN 4170-30-3) ; Formaldehyde (CAS RN 50-00-0) ; Furfural (CAS RN 98-01-1) ; Glutaraldehyde (CAS RN 111-30-8) ; Hydroxyamine hydrochloride (CAS RN 5470-11-1)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of California Los Angeles, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19950901
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• End Date:
  19990831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0b49abc9969b87e56e8dc58ec5335d4647ed42597e2f273c951088105616cac19fcc46378832754bb5c089ffbdf71bee3d83b3c41e9819148611edb9da2f602e
• Download URL:
  https://stacks.cdc.gov/view/cdc/190751/cdc_190751_DS1.pdf
• File Type:
  [PDF - 320.52 KB ]