Local and Systemic Toxicity of JP-8 from Cutaneous Exposures

Details

• Personal Author:
  McDougal JN ; Rogers JV
• Description:
  Jet propellant-8 (JP-8) jet fuel is a version of commercial jet fuel, Jet A, and is a complex mixture of primarily aliphatic (but also aromatic) hydrocarbons that varies in composition from batch to batch. There is potential for dermal exposure to jet fuels with personnel involved in aircraft refueling and maintenance operations as well as ground personnel. Cutaneous exposures have the potential to cause skin irritation, sensitization or skin cancer. JP-8 has been shown to be irritating and causes molecular changes in the skin of laboratory animals. The mechanisms of some of these effects have been investigated in intact skin and cultured skin cells. Hydrocarbons have also been shown to cause skin cancer with repeated application to the skin. Additionally, there is concern about systemic toxicity from dermal exposures to jet fuels, such as JP-8. Assessing risks from systemic absorption of hydrocarbon components is complex because most of the components are present in the mixture in small quantities (less than 1%). The effect of the fuel as a vehicle, different rates of penetration through the skin and different target organ toxicities all complicate the assessment of the hazards of cutaneous exposures. The purpose of this manuscript is to review studies of local and systemic toxicity of JP-8. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Dermatitis Environmental Monitoring Fuel Oils Occupational Health Petroleum Safety Skin Skin Diseases
• Keywords:
  Cytotoxic-effects Cytotoxicity Dermatosis Exposure-assessment Exposure-levels Exposure-limits Fuels Petroleum-products Skin-exposure Skin-irritants
• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  301-398
• Volume:
  149
• Issue:
  1
• NIOSHTIC Number:
  nn:20029458
• Citation:
  Toxicol Lett 2004 Apr; 149(1-3):301-398
• Contact Point Address:
  Department of Pharmacology and Toxicology, Wright State University School of Medicine, 3640 Col Glenn Highway, Dayton, OH 45435
• Email:
  james.mcdougal@wright.edu
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  Wright State University, Dayton, Ohio
• Peer Reviewed:
  True
• Start Date:
  19980930
• Source Full Name:
  Toxicology Letters
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e96bedb11eb301ad5f0071fffcda6cb3be806e23942351172fa8444a6f8cb7d70f39ab8094afbcad114079edff47c7cb7435dc360a237af9ae8a54153e1a342
• Download URL:
  https://stacks.cdc.gov/view/cdc/190435/cdc_190435_DS1.pdf
• File Type:
  [PDF - 97.64 KB ]