In Vivo Evaporation Rate of Benzyl Alcohol from Human Skin

Details

• Personal Author:
  Kasting GB ; Saiyasombati P
• Description:
  The evaporation rate of benzyl alcohol from the human volar forearm under controlled conditions in vivo shows a similar dependence on airflow and time to that seen in earlier in vitro studies. After an initial time lag associated with the apparatus, evaporation rate over a 2-h time period post-dose was satisfactorily described by a single exponential decay with a rate constant proportional to airflow over the skin, nu. The cumulative percentage of dose evaporated after 2 h ranged from 16% at nu = 20 mL min(-1) to 52% at nu = 100 mL min(-1). The absorption rate constant determined by an analysis of the in vivo data was equivalent to that determined in vitro, whereas the evaporation rate constants were related by the inverse ratio of the headspace volumes. The latter finding suggests that a simple laminar flow model can satisfactorily describe evaporation in both systems over the range of airflows used. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption
• Keywords:
  Alcohols Humans In-vitro-studies In-vitro-study In-vivo-study Models Skin-absorption
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  93
• Issue:
  2
• NIOSHTIC Number:
  nn:20029377
• Citation:
  J Pharm Sci 2004 Feb; 93(2):515-520
• Contact Point Address:
  Gerald B. Kasting, College of Pharmacy, The University of Cincinnati Medical Center, P.O. Box 670004, Cincinnati, Ohio 45267-0004, USA
• Email:
  gerald.kasting@uc.edu
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0fb05bd3b6b5e3b45f6623a544f6fb2142eaa68e7226fa9d707f10d816696532f466886e81d2df050390ed17a34a060448e53ce40da92bbe057aea867a9f7250
• Download URL:
  https://stacks.cdc.gov/view/cdc/190367/cdc_190367_DS1.pdf
• File Type:
  [PDF - 100.38 KB ]