Ototoxic Effects of Carbon Monoxide Exposure: A Review

Details

• Personal Author:
  Lacerda A ; Leroux T ; Morata, Thais C.
• Description:
  Ototoxic effects of carbon monoxide exposure: a review. To analyze the literature on hearing and Carbon Monoxide (CO). To describe the physical properties, the absorption, distribution and metabolism of CO, as well as its origin, production, sources and the international standards for occupational exposure. Several studies about the effects of CO exposure to the auditory system of humans and experimental animals were discussed. The main economic sectors where the combined exposure to noise and CO takes place were identified. A description of the basic CO toxic mechanisms that are able to raise occupational noise-induced hearing loss was given. The review of the literature indicated the following: 1. Examples of CO exposure sources include air pollution, smoking and second-hand smoking, and occupational exposures. 2. CO's main toxic mechanism can lead to hypoxia due to the conversion of oxyhemoglobin to carboxyhemoglobin. 3. Rats have been the most used experimental animals in CO auditory effects studies, this group of studies has demonstrated the combined effects of acute exposure to CO and noise. 4. Studies about the negative effects of CO exposure over the human auditory system were mainly carried out after acute exposures to CO. These studies did not control or report exposure to noise as a contributor to the observed hearing deficits. Currently the available evidence indicates the need for further research on the effects of CO exposure to the auditory system, alone or in combination with noise. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Occupational Exposure Occupational Health Safety Smokers
• Keywords:
  Acute-exposure Animal-studies Auditory-system Hearing-loss Humans Laboratory-animals Noise-exposure Noise-induced-hearing-loss Occupational-exposure Ototoxicity Smoking Toxic-effects Toxins

  More +
• ISSN:
  0104-5687
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  403-412
• Volume:
  17
• Issue:
  3
• NIOSHTIC Number:
  nn:20029314
• Citation:
  Pro Fono 2005 Apr-Dec; 17(3):403-412
• Email:
  adriana.lacerda@umontreal.ca
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Pro-fono: Revista de Atualizacao Cientifica
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0f53a05c8cb45873bde0f30502c669556cc5a34b5d136e9f977b7dbaf864b7e2072aef78b1f52e308032426db64f1df3ae77d57642817883552c83bbf93c61b
• Download URL:
  https://stacks.cdc.gov/view/cdc/190333/cdc_190333_DS1.pdf
• File Type:
  [PDF - 42.79 KB ]