Effects of Alcohol and Tobacco on Aerodigestive Cancer Risks: A Meta-Regression Analysis

Details

• Personal Author:
  Gore R ; Kriebel D ; Zeka A
• Description:
  Meta-analysis was used to summarize the published evidence on the associations between alcohol and tobacco consumption and cancers of the oropharynx, pharynx, larynx, and esophagus. The objective was to produce summary risk estimates with uniform methods and on uniform exposure scales so that the magnitudes of the risks could be compared across tumor sites. Epidemiologic studies that estimated the effects of alcohol and tobacco consumption on the risk of cancers of the upper aero-digestive tract were identified from the MEDLINE database, 1966-2001. Alcohol and tobacco data were converted into common units (grams/week). For all studies meeting eligibility criteria, effect parameters (slopes) were estimated for both exposures. The exposure-risk slopes for each study were combined, site by site, using random effects meta-regression methods. Fourteen studies met the final selection criteria. The carcinogenic effects of alcohol and tobacco were found to be multiplicative on the relative risk scale. Tobacco appeared to have a much stronger effect on the larynx than on any of the other aerodigestive sites, while alcohol's effect was strongest on the pharynx. The weakest association was that of alcohol and adenocarcinoma of the esophagus--an order of magnitude weaker than that for tobacco and laryngeal cancer. Meta-analysis was used to combine the results from all available studies, providing a comprehensive summary of the combined effects of alcohol and tobacco on the upper aerodigestive cancers. [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Carcinogens Environmental Monitoring Epidemiology Neoplasms Occupational Health Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Smokers Tobacco Products

  More +
• Keywords:
  Alcoholism Alcohols Author Keywords: Alcohol Drinking Cancer Carcinogenesis Carcinogenicity Digestive-system Digestive System Neoplasms Exposure-assessment Exposure-levels Meta-analysis Respiratory-system-disorders Respiratory Tract Neoplasms Risk-analysis Risk-factors Smoking Tobacco Tobacco-smoke

  More +
• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  9
• NIOSHTIC Number:
  nn:20029278
• Citation:
  Cancer Causes Control 2003 Nov; 14(9):897-906
• Contact Point Address:
  Department of Work Environment, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA
• Email:
  David_Kriebel@uml.edu
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Causes and Control
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ecc7fae49625c8ede74f033e716a536caca1c35c4829e8ed2b6a0ec5af10dc97464a981fc08218586b04804fd045c12eafbed73f0b6b2ce50cbf71588dec58f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/190305/cdc_190305_DS1.pdf
• File Type:
  [PDF - 545.27 KB ]