Respiratory Burst: Role in Signal Transduction in Alveolar Macrophages

Details

• Personal Author:
  Gwinn MR ; Vallyathan V
• Description:
  Alveolar macrophages play an important role in defense against airborne pathogens and particles. These macrophages respond through both the adaptive and acquired immune responses, and through the activation of a multitude of signaling pathways. One major macrophage defense mechanism is respiratory burst, the production of reactive oxygen species (ROS). While the ROS produced may act directly in pathogen killing, they may also be involved as secondary signaling messengers. This review focuses on the activation of four main signaling pathways following the production of reactive oxygen species. These pathways include the nuclear factor kappa beta (NFkB), activating protein-1 (AP-1), mitogen-activating protein kinase (MAPK), and phosphotidyl inositol-3 kinase (PI3K) pathways. This review also briefly examines the role of ROS in DNA damage, in particular looking at the base excision repair pathway (BER), the main pathway involved in repair of oxidative DNA damage. This review highlights many of the studies in the field of ROS, signal transduction, and DNA damage; however, work still remains to further elucidate the role of ROS in disease. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Antioxidants DNA Dust Immune System Occupational Health Particulate Matter Safety
• Keywords:
  Airborne-dusts Airborne-particles Cell-function Cellular-function Diseases DNA-damage Immune-reaction
• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  27-39
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20029232
• Citation:
  J Toxicol Environ Health B 2006 Jan-Feb; 9(1):27-39
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f1262072cead437903228c243a133c2400c2d7fd33772d6a5887115380d7eda8464d3e1115f9105ceb04cf0c41191d401d7faf999cd2de89d1e5bb09d37f9fdd
• Download URL:
  https://stacks.cdc.gov/view/cdc/190265/cdc_190265_DS1.pdf
• File Type:
  [PDF - 220.60 KB ]