Iron Overload and Its Association with Cancer Risk in Humans: Evidence for Iron as a Carcinogenic Metal

Details

• Personal Author:
  Huang X
• Description:
  Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this review, evidence for iron as a carcinogenic metal was summarized from epidemiological, animal, and cell culture studies. The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. These include: (1) iron autoxidation involving only Fe(2+)+O2 in oxidant formation in biological systems and its pH dependency; (2) activation of oxidative responsive transcription factors and pro-inflammatory cytokines; and (3) iron-induced hypoxia signaling. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Cells, Cultured Epidemiology Ferrous Compounds Metals Neoplasms Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Animal-studies Cancer Carcinogenesis Carcinogenicity Cell-cultures Humans Iron-compounds Metal-compounds Risk-analysis Risk-factors
• ISSN:
  0027-5107
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  153-171
• Volume:
  533
• Issue:
  1
• NIOSHTIC Number:
  nn:20029191
• Citation:
  Mutat Res 2003 Dec; 533(1-2):153-171
• Contact Point Address:
  Department of Environmental Medicine, NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
• Email:
  xihuang@env.med.nyu.edu
• CAS Registry Number:
  Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2004
• Performing Organization:
  New York University Medical Center, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19990930
• Source Full Name:
  Mutation Research
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c504c8e31d7c0081c9681594ae7b0fa6775d332d1ece23b38636714a0ad37fad19c188988e08d5395d45b401107b79ab57688d31769eb7eb235be0e86960064
• Download URL:
  https://stacks.cdc.gov/view/cdc/190230/cdc_190230_DS1.pdf
• File Type:
  [PDF - 191.95 KB ]