Comment on “Relative Susceptibility of Animals and Humans to the Cancer Hazard Posed by 2,3, 7,8-Tetrachlorodibenzo-P-Dioxin Using Internal Measures of Dose.

Details

• Personal Author:
  Dankovic, David A. ; Stayner, Leslie T.
• Description:
  Aylward et al. (1) are to be commended for their attempt to use empirical data to address the question of whether the carcinogenicity of TCDD in humans is quantitatively similar to that observed in animals. However, we disagree with the authors' interpretation of their results. The empirical evidence presented by Aylward et al. (1) does not lend support to the use of area under the concentration-time curve (AUC) as a dose metric for cross-species extrapolation of toxicity and does not support the authors' conclusion that "humans are much less sensitive than rats to the carcinogenic effects of TCDD". A more appropriate conclusion to draw from their analysis would be that it lends empirical support to the use of lifetime average concentration as a dose metric for cross-species scaling of TCDD carcinogenicity. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chemistry Epidemiology Laboratories Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Cancer-rates Carcinogenesis Carcinogenicity Chemical-properties Humans Laboratory-animals Risk-analysis Risk-factors
• ISSN:
  0013-936X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  4
• NIOSHTIC Number:
  nn:20033954
• Citation:
  Environ Sci Technol 1998 Feb; 32(4):549-550
• Contact Point Address:
  David A. Dankovic, NIOSH, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, OH 45226
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  False
• Source Full Name:
  Environmental Science and Technology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:926a4e70e9fc0f8154a0c7d2a746740c1bdc45af1c77034ff0d0e5b347835bd96ebfa72b4d9027c56d62a6a66063e3cb8987f08e9263ce66d81ab8a4710a0791
• Download URL:
  https://stacks.cdc.gov/view/cdc/189350/cdc_189350_DS1.pdf
• File Type:
  [PDF - 17.06 KB ]