Transmission of Mycobacterium tuberculosis Beijing Strains, Alberta, Canada, 1991–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Langlois-Klassen, Deanne ; Senthilselvan, Ambikaipakan ; Chui, Linda ; Kunimoto, Dennis ; Saunders, L. Duncan ; Menzies, Dick ; Long, Richard
• Description:
  Beijing strains are speculated to have a selective advantage over other Mycobacterium tuberculosis strains because of increased transmissibility and virulence. In Alberta, a province of Canada that receives a large number of immigrants, we conducted a population-based study to determine whether Beijing strains were associated with increased transmission leading to disease compared with non-Beijing strains. Beijing strains accounted for 258 (19%) of 1,379 pulmonary tuberculosis cases in 1991-2007; overall, 21% of Beijing cases and 37% of non-Beijing cases were associated with transmission clusters. Beijing index cases had significantly fewer secondary cases within 2 years than did non-Beijing cases, but this difference disappeared after adjustment for demographic characteristics, infectiousness, and M. tuberculosis lineage. In a province that has effective tuberculosis control, transmission of Beijing strains posed no more of a public health threat than did non-Beijing strains.
• Subjects:
  Adult Aged Emigrants And Immigrants Female Genotype Humans Incidence Male Middle Aged Mycobacterium Tuberculosis Registries Retrospective Studies Sputum Time Factors Tuberculosis, Pulmonary

  More +
• Source:
  Emerg Infect Dis. 19(5):701-711.
• Document Type:
  Journal Article
• Place as Subject:
  Canada
• Location:
  North America
• Volume:
  19
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8ce2d2b5643988fd3a45f84674f6872805d3d717500caf5f7c0a13e8724ad079
• Download URL:
  https://stacks.cdc.gov/view/cdc/19019/cdc_19019_DS1.pdf
• File Type:
  [PDF - 3.56 MB ]