Chronic Repetitive Reaching and Grasping Results in Decreased Motor Performance and Widespread Tissue Responses in a Rat Model of MSD

Details

• Personal Author:
  Amin M ; Barbe MF ; Barr AE ; Gaughan JP ; Gorzelany I ; Safadi FF
• Description:
  This study investigated changes in motor skills and tissues of the upper extremity (UE) with regard to injury and inflammatory reactions resulting from performance of a voluntary forelimb repetitive reaching and grasping task in rats. Rats reached for food at a rate of 4 reaches/min, 2 h/day, and 3 days/week for up to 8 weeks during which reach rate, task duration and movement strategies were observed. UE tissues were collected bilaterally at weekly time points of 3-8 weeks and examined for morphological changes. Serum was tested for levels of interleukin-1alpha (IL-1) protein. The macrophage-specific antibody, ED1, was used to identify infiltrating macrophages and the ED2 antibody was used to identify resident macrophages. Rats were unable to maintain baseline reach rate in weeks 5 and 6 of task performance. Alternative patterns of movement emerged. Fraying of tendon fibrils was observed after 6 weeks in the mid-forelimb. After 4 weeks, a general elevation of ED1-IR macrophages were seen in all tissues examined bilaterally including the contralateral, uninvolved forelimb and hindlimbs. Significantly more resident macrophages were seen at 6 and 8 weeks in the reach limb. At 8 weeks, serum levels of IL-1alpha increased significantly above week 0. Our results demonstrate that performance of repetitive tasks elicits motor decrements, signs of injury and a cellular and tissue responses associated with inflammation. [Description provided by NIOSH]
• Subjects:
  Animals Cumulative Trauma Disorders Ergonomics Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Cellular-reactions Cumulative-trauma Cumulative-trauma-disorders Injuries Laboratory-animals Models Morphology Repetitive-work
• ISSN:
  0736-0266
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  167-176
• Volume:
  21
• Issue:
  1
• NIOSHTIC Number:
  nn:20029137
• Citation:
  J Orthop Res 2003 Jan; 21(1):167-176
• Contact Point Address:
  Department of Physical Therapy, College of Allied Health Professions, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA
• Email:
  mbarbe@temple.edu
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Temple University
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Journal of Orthopaedic Research
• End Date:
  20120731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d5462325f2fe00692f9132d6562fbc74da7aa303c67f71559eaf7fa8fe77bde1d0824a33f2a794aab013072dfa995888a9e9cfba1d08c766c7985d70a189345
• Download URL:
  https://stacks.cdc.gov/view/cdc/190189/cdc_190189_DS1.pdf
• File Type:
  [PDF - 1010.39 KB ]