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Serum and Tissue Cytokines and Chemokines Increase with Repetitive Upper Extremity Tasks



Details

  • Personal Author:
  • Description:
    This study investigated changes in motor skills and tissues of the upper extremity (UE) with regard to injury and inflammatory reactions resulting from performance of a voluntary forelimb repetitive reaching and grasping task in rats. Rats reached for food at a rate of 4 reaches/min, 2 h/day, and 3 days/week for up to 8 weeks during which reach rate, task duration and movement strategies were observed. UE tissues were collected bilaterally at weekly time points of 3-8 weeks and examined for morphological changes. Serum was tested for levels of interleukin-1alpha (IL-1) protein. The macrophage-specific antibody, ED1, was used to identify infiltrating macrophages and the ED2 antibody was used to identify resident macrophages. Rats were unable to maintain baseline reach rate in weeks 5 and 6 of task performance. Alternative patterns of movement emerged. Fraying of tendon fibrils was observed after 6 weeks in the mid-forelimb. After 4 weeks, a general elevation of ED1-IR macrophages were seen in all tissues examined bilaterally including the contralateral, uninvolved forelimb and hindlimbs. Significantly more resident macrophages were seen at 6 and 8 weeks in the reach limb. At 8 weeks, serum levels of IL-1alpha increased significantly above week 0. Our results demonstrate that performance of repetitive tasks elicits motor decrements, signs of injury and a cellular and tissue responses associated with inflammation. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0736-0266
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    21
  • Issue:
    1
  • NIOSHTIC Number:
    nn:20034686
  • Citation:
    J Orthop Res 2008 Oct; 26(1):1320-1326
  • Contact Point Address:
    Mary F. Barbe, Department of Physical Therapy, College of Health Professions, Temple University, 3307 North Broad Streeet, Philadelphia, PA 19140
  • Email:
    mary.barbe@temple.edu
  • Federal Fiscal Year:
    2009
  • NORA Priority Area:
  • Performing Organization:
    Temple University
  • Peer Reviewed:
    True
  • Start Date:
    20000601
  • Source Full Name:
    Journal of Orthopaedic Research
  • End Date:
    20120731
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:4bfe7afad83ef27250bc524b223cb84864a06e97bf813102c8c054a1044262ee2c25014138e424f88930531d49ab26fef2624fc713a2b7c9b1bd1326f5346e22
  • Download URL:
  • File Type:
    Filetype[PDF - 305.86 KB ]
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