Vibration-Induced Disruption of Retrograde Axoplasmic Transport in Peripheral Nerve

Details

• Personal Author:
  Matloub, Hani S. ; Riley, Danny A. ; Sanger JR ; Yan JG ; Zhang LL ; Matloub, Hani S. ; Riley, Danny A. ; Sanger JR ; Yan JG ; Zhang LL
• Description:
  Hand-arm vibration syndrome (HAVS) results from excessive exposure to hand-transmitted vibration. Whether the peripheral nerve damage characteristic of HAVS is a direct result of vibration or is secondary to vascular insufficiency remains unclear. The purpose of this study was to explore the effect of vibration exposure on axoplasmic transport in peripheral nerves and soleus motor neurons. Sciatic nerves and motor neurons from rats following two 5-h periods of vibration exposure demonstrated disruption in retrograde transport compared to normal. After 10 days of vibration (5 h/day), axoplasmic transport failed to recover within 24-48 h in most rats. This study demonstrates that disrupted axoplasmic transport is an early consequence of short-term vibration exposure. The effects of vibration on axoplasmic transport also appear to be cumulative. This study provides a new biological way to evaluate measures to prevent early vibration injury. [Description provided by NIOSH]
• Subjects:
  Musculoskeletal System Occupational Exposure Occupational Health Safety Vibration
• Keywords:
  Arm-injuries Diseases Hand-injuries Injuries Injury-prevention Nerve-damage Neuropathy Occupational-exposure Vibration-disease Vibration-effects Vibration-exposure

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• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  32
• Issue:
  4
• NIOSHTIC Number:
  nn:20029072
• Citation:
  Muscle Nerve 2005 Oct; 32(4):521-526
• Contact Point Address:
  Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
• Email:
  hmatloub@mcw.edu
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities ; Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Muscle & Nerve
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f37f498a71885148266ee0b9eaf8bd73b4c92f5300166d6f36676d6153f7d14e43053e5aaf10d36c8c6e624e69227402374022f91e4871fd0588953dd07d39e2
• Download URL:
  https://stacks.cdc.gov/view/cdc/190139/cdc_190139_DS1.pdf
• File Type:
  [PDF - 206.43 KB ]