Tumor Necrosis Factor-Alpha Hyper-Responsiveness to Endotoxin in Whole Blood Is Associated with Chronic Bronchitis in Farmers

Details

• Personal Author:
  Lambert GP ; Lyden E ; Merchant, James A. ; Romberger DJ ; Spurzem JR ; Stromquist AM ; Von Essen, Susanna ; Wyatt TA
• Description:
  Many farmers experience chronic bronchitis, airflow obstruction, and asthma. It is thought that these respiratory problems may be related to workplace inhalation of organic dust containing endotoxin. The purpose of this study was to determine whether whole blood cytokine responsiveness to endotoxin is associated with airflow disorders (i.e., airflow obstruction, chronic bronchitis, and doctor-diagnosed asthma). Farmers (N = 95) were recruited from a rural cohort study and completed a respiratory symptom and history questionnaire, spirometry, and blood sampling. Blood was incubated 24 hours in the presence and absence of endotoxin and supernatants were analyzed for TNF-alpha, IL-1beta, IL-6, and IL-8. Hypo- or hyper-responsiveness to endotoxin was based on whether cytokine values were in the lower or upper 10% of the group range, respectively. A significant association existed between TNF-alpha hyper-responsiveness and chronic bronchitis. These results indicate that the whole blood cytokine assay may be useful to identify individual responsiveness to endotoxin, and may provide an additional diagnostic tool to evaluate persons potentially at risk for developing chronic bronchitis following exposure to organic dust in the workplace. [Description provided by NIOSH]
• Subjects:
  Agriculture Asthma Asthma, Occupational Dust Endotoxins Environmental Monitoring Farmers Hematologic Tests Occupational Exposure Occupational Health Respiratory Function Tests Safety Surveys And Questionnaires

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• Keywords:
  Agricultural-workers Airway-obstruction Blood-sampling Exposure-assessment Occupational-exposure Organic-dusts Questionnaires Spirometry
• ISSN:
  1059-924X
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-44
• Volume:
  10
• Issue:
  1
• NIOSHTIC Number:
  nn:20028839
• Citation:
  J Agromedicine 2005 Jan; 10(1):39-44
• Email:
  plambert@creighton.edu
• Federal Fiscal Year:
  2005
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Agromedicine
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e397d707bf2e5c8cfb75f85e0caf53c84c37397003499ce7c0226bd9425637ad6f3fcc6f764b4b83dda0d279e1c55d7676b52025ed5717b156ce690fbfd1100b
• Download URL:
  https://stacks.cdc.gov/view/cdc/189944/cdc_189944_DS1.pdf
• File Type:
  [PDF - 758.48 KB ]