Mortality Studies of Metalworking Fluid Exposure in the Automobile Industry V: A Case-Control Study of Pancreatic Cancer

Details

• Personal Author:
  Bardin JA ; Eisen EA ; Hallock MF ; Hammond SK ; Monson RR ; Smith, Thomas J. ; Tolbert PE ; Woskie SR
• Description:
  Results are presented from a case-control study of 97 cases of pancreatic cancer nested in a cohort of workers from three automobile manufacturing plants. Risk was examined for lifetime exposure to straight, soluble and synthetic metalworking fluids, as used in specific machining or grinding operations, as well as for constituents of the fluids. Pancreatic cancer was associated with exposure to synthetic fluids in grinding operations, with an odds ratio of 3.0 (95% CI: 1.2-7.5) among those with more than 1.4 mg/m3 - years of exposure. We were unable to examine synthetic exposure in the absence of grinding, because there was virtually no exposure to synthetics in machining operations in this study population. Despite a disproportionately high percent of the cases being black, no black workers had any exposure to synthetic fluids, and no other measured exposre was found to be related to risk. Thus, the previously documented excess risk of pancreas cancer among blacks in this cohort remains unexplained. [Description provided by NIOSH]
• Subjects:
  Fires Mining Occupational Health Safety
• Keywords:
  Automotive-industry Cancer Case-studies Endocrine-system Endocrine-system-disorders Exposure-assessment Exposure-levels Metalworking Metalworking-fluids Metalworking-industry Mortality-data Mortality-rates Risk-analysis Risk-factors Workers

  More +
• ISBN:
  1893348008
• Publisher:
  American Automobile Manufacturers Association
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  California ; District of Columbia ; Georgia ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  132-135
• NIOSHTIC Number:
  nn:20028451
• Citation:
  Metalworking Fluids Symposium II, The Industrial Metalworking Environment: Assessment and Control of Metal Removal Fluids. September 15-17, 1997, Detroit, Michigan. DA Felinski, JB D'ARcy, eds., Washington, DC: American Automobile Manufacturers Association, 1998 Nov; :132-135
• Editor(s):
  Felinski DA; D'Arcy JB
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Start Date:
  19930901
• Source Full Name:
  Metalworking Fluids Symposium II, The Industrial Metalworking Environment: Assessment and Control of Metal Removal Fluids. September 15-17, 1997, Detroit, Michigan
• End Date:
  19950831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7f6ab1ce9a6e1dab882e241b764152fcd651a6b09b1ad3bdb91c7c3ce255fb75f3d04ba2d77394a203cc25fdab9c55e701478b9c718cad230355b5e93d8569c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/189857/cdc_189857_DS1.pdf
• File Type:
  [PDF - 794.13 KB ]