Methodologic Issues Concerning Stachyhemolysin and Stachyrase-A as Clinical Biomarkers

Details

• Personal Author:
  Beezhold, Donald H. ; Biagini, Raymond E. ; Page, Elena H. ; Beezhold, Donald H. ; Biagini, Raymond E. ; Page, Elena H.
• Description:
  We are writing about the recently published article "Antibodies against Stachybotrys chartarum extract and its antigenic components, Stachyhemolysin and Stachyrase-A: a new clinical biomarker" [1]. The author states that his hypothesis is "that environmental exposure to Stachyhemolysin and Stachyrase-A may result in antibody production against these mold antigens." There are numerous methodologic defi ciencies in this paper which preclude drawing any conclusions regarding the utility of anti-stachyhemolsyin and anti-stachyrase-A antibodies as biomarkers. In closing, we feel there are signifi cant problems with this paper which preclude the author's conclusions that antibodies to Stachyhemolysin and Stachyrase-A are new clinical biomarkers of exposure to Stachybotrys chartarum. The fi ndings and conclusions in this letter to the editor are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. [Description provided by NIOSH]
• Subjects:
  Antibodies Biomarkers Environmental Exposure Environmental Monitoring Occupational Health Safety
• Keywords:
  Antibody-response Environmental-exposure Exposure-assessment Exposure-levels Exposure-limits
• ISSN:
  1234-1010
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology ; HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  11
• Issue:
  9
• NIOSHTIC Number:
  nn:20028434
• Citation:
  Med Sci Monit 2005 Sep; 11(9):LE7-LE8
• Email:
  EPage@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Medical Science Monitor
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7db12e5460e5e0247bd5f02bf1ae74c0f0391afa108e61a84af2e73b248875c8dd6b98282a66bdd6c2198b887554400e783f44f4a7097690ef6700cd340dff68
• Download URL:
  https://stacks.cdc.gov/view/cdc/189851/cdc_189851_DS1.pdf
• File Type:
  [PDF - 45.47 KB ]