Phylogenetic and Ecologic Perspectives of a Monkeypox Outbreak, Southern Sudan, 2005

Nakazawa, Yoshinori; Emerson, Ginny L.; Carroll, Darin S.; Zhao, Hui; Li, Yu; Reynolds, Mary G.; Karem, Kevin L.; Olson, Victoria A.; Lash, R. Ryan; Davidson, Whitni B.; Smith, Scott K.; Levine, Rebecca S.; Regnery, Russell L.; Sammons, Scott A.; Frace, Michael A.; Mutasim, Elmangory M.; Karsani, Mubarak E. M.; Muntasir, Mohammed O.; Babiker, Alimagboul A.; Opoka, Langova; Chowdhary, Vipul; Damon, Inger K.

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Phylogenetic and Ecologic Perspectives of a Monkeypox Outbreak, Southern Sudan, 2005

Supporting Files Public Domain

Feb 2013
By Nakazawa, Yoshinori ; Emerson, Ginny L. ; Carroll, Darin S. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Nakazawa, Yoshinori ; Emerson, Ginny L. ; Carroll, Darin S. ; Zhao, Hui ; Li, Yu ; Reynolds, Mary G. ; Karem, Kevin L. ; Olson, Victoria A. ; Lash, R. Ryan ; Davidson, Whitni B. ; Smith, Scott K. ; Levine, Rebecca S. ; Regnery, Russell L. ; Sammons, Scott A. ; Frace, Michael A. ; Mutasim, Elmangory M. ; Karsani, Mubarak E. M. ; Muntasir, Mohammed O. ; Babiker, Alimagboul A. ; Opoka, Langova ; Chowdhary, Vipul ; Damon, Inger K.
Description:

Identification of human monkeypox cases during 2005 in southern Sudan (now South Sudan) raised several questions about the natural history of monkeypox virus (MPXV) in Africa. The outbreak area, characterized by seasonally dry riverine grasslands, is not identified as environmentally suitable for MPXV transmission. We examined possible origins of this outbreak by performing phylogenetic analysis of genome sequences of MPXV isolates from the outbreak in Sudan and from differing localities. We also compared the environmental suitability of study localities for monkeypox transmission. Phylogenetically, the viruses isolated from Sudan outbreak specimens belong to a clade identified in the Congo Basin. This finding, added to the political instability of the area during the time of the outbreak, supports the hypothesis of importation by infected animals or humans entering Sudan from the Congo Basin, and person-to-person transmission of virus, rather than transmission of indigenous virus from infected animals to humans.
Subjects:

Animals Disease Outbreaks Genes, Viral Humans Molecular Typing Monkeypox Virus Phylogeny Phylogeography Sequence Analysis, DNA
Source:

Emerg Infect Dis. 19(2):237-245.
Document Type:

Journal Article
Place as Subject:

Sudan ; South Sudan
Volume:

19
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:df19fd7221cda22cda6b9f04582949f70938a67248203bfae0af7e8e789b6fa8
Download URL:

https://stacks.cdc.gov/view/cdc/18977/cdc_18977_DS1.pdf
File Type:

[PDF - 1.56 MB ]

File Language:

English

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