Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Afonso, Eliane Terezinha ; Minamisava, Ruth ; Bierrenbach, Ana Luiza ; Escalante, Juan Jose Cortez ; Alencar, Airlane Pereira ; Domingues, Carla Magda ; Morais-Neto, Otaliba Libanio ; Toscano, Cristiana Maria ; Andrade, Ana Lucia
• Description:
  Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccine's effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 2-24 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis for 5 cities in Brazil that had good data quality and high PCV10 vaccination coverage. Of the 197,975 hospitalizations analyzed, 30% were for pneumonia. Significant declines in hospitalizations for pneumonia were noted in Belo Horizonte (28.7%), Curitiba (23.3%), and Recife (27.4%) but not in São Paulo and Porto Alegre. However, in the latter 2 cities, vaccination coverage was less than that in the former 3. Overall, 1 year after introduction of PCV10, hospitalizations of children for pneumonia were reduced.
• Subjects:
  Child, Preschool Cost-Benefit Analysis Female Hospitalization Humans Immunization Programs Infant Male Pneumococcal Vaccines Pneumonia, Pneumococcal Streptococcus Pneumoniae Urban Population Vaccination Vaccines, Conjugate

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• Source:
  Emerg Infect Dis. 19(4):589-597.
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  19
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8dae281e5bc4fe102ebaabcf89e89fb6b44c7c0434a1dfee7be403f149118cfa
• Download URL:
  https://stacks.cdc.gov/view/cdc/18973/cdc_18973_DS1.pdf
• File Type:
  [PDF - 713.91 KB ]