Survey of Sulfur-Containing Rubber Accelerator Levels in Latex and Nitrile Exam Gloves

Details

• Personal Author:
  Bledsoe TA ; Depree GJ ; Siegel, Paul D.
• Description:
  2-Mercaptobenzothiazole and zinc dialkyldithiocarbamates are commonly used sulfur-containing rubber vulcanization accelerators known to cause allergic contact dermatitis. Exposure to these agents occurs through clothing such as undergarments and shoes, latex medical devices and latex and nitrile gloves. A simple, inexpensive screening method for total sulfur accelerator and a high performance liquid chromatographic speciation method were developed in the present study. These methods were applied to screen and quantify the sulfur accelerator content from 38 brands of 'off-the-shelf' latex and nitrile gloves obtained from commercial vendors. It was found that accelerator levels ranged from not detectable to 7.35 mg/g in the gloves analysed. Brands were found to contain single and multiple accelerator species within the glove. Powdered gloves had significantly higher accelerator levels than powder-free gloves from the same manufacturer; however, these chemical accelerators do not preferentially partition to the powder. The present analytical methodology is suitable for both manufacturing quality validation purposes, as well as for accelerator allergy research. [Description provided by NIOSH]
• Subjects:
  Dermatitis Hypersensitivity Nitriles Occupational Exposure Occupational Health Personal Protective Equipment Protective Clothing Safety Safety Management Skin Skin Diseases

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• Keywords:
  Allergic-dermatitis Allergic-reactions Contact-dermatitis Gloves Occupational-exposure Safety-clothing Safety-measures Safety-research
• ISSN:
  0105-1873
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  107-113
• Volume:
  53
• Issue:
  2
• NIOSHTIC Number:
  nn:20027920
• Citation:
  Contact Dermatitis 2005 Aug; 53(2):107-113
• Contact Point Address:
  Paul D. Siegel, PhD, Allergy and Clinical Immunology Branch, M/S L4020, HELD/NIOSH, 1095 Willowdale Road, Morgantown WV 26505-2888, USA
• Email:
  PSiegel@cdc.gov
• CAS Registry Number:
  2-Mercaptobenzothiazole (CAS RN 149-30-4)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Peer Reviewed:
  True
• Source Full Name:
  Contact Dermatitis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b849c1b34367095afb7bc3c37f2ec23d58d65b6ae880238f06295508bc9884a09746f49a9c1d5e48b2a6d164f42fb4c745748aca8325000c4f688fc45206654a
• Download URL:
  https://stacks.cdc.gov/view/cdc/189675/cdc_189675_DS1.pdf
• File Type:
  [PDF - 694.24 KB ]