Microevolution of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Humans, Egypt, 2007–2011

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Younan, Mary ; Poh, Mee Kian ; Elassal, Emad ; Davis, Todd ; Rivailler, Pierre ; Balish, Amanda L. ; Simpson, Natosha ; Jones, Joyce ; Deyde, Varough ; Loughlin, Rosette ; Perry, Ije ; Gubareva, Larisa ; ElBadry, Maha A. ; Truelove, Shaun ; Gaynor, Anne M. ; Mohareb, Emad ; Amin, Magdy ; Cornelius, Claire ; Pimentel, Guillermo ; Earhart, Kenneth ; Naguib, Amel ; Abdelghani, Ahmed S. ; Refaey, Samir ; Klimov, Alexander I. ; Donis, Ruben O. ; Kandeel, Amr
• Description:
  We analyzed highly pathogenic avian influenza A(H5N1) viruses isolated from humans infected in Egypt during 2007-2011. All analyzed viruses evolved from the lineage of subtype H5N1 viruses introduced into Egypt in 2006; we found minimal evidence of reassortment and no exotic introductions. The hemagglutinin genes of the viruses from 2011 formed a monophyletic group within clade 2.2.1 that also included human viruses from 2009 and 2010 and contemporary viruses from poultry; this finding is consistent with zoonotic transmission. Although molecular markers suggestive of decreased susceptibility to antiviral drugs were detected sporadically in the neuraminidase and matrix 2 proteins, functional neuraminidase inhibition assays did not identify resistant viruses. No other mutations suggesting a change in the threat to public health were detected in the viral proteomes. However, a comparison of representative subtype H5N1 viruses from 2011 with older subtype H5N1 viruses from Egypt revealed substantial antigenic drift.
• Subjects:
  Animals Antigens, Viral Chickens Enzyme Assays Evolution, Molecular Genes, Viral Genetic Drift Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza A Virus, H5N1 Subtype Neuraminidase Phylogeny Poultry Diseases

  More +
• Source:
  Emerg Infect Dis. 19(1):43-50.
• Document Type:
  Journal Article
• Place as Subject:
  Egypt
• Location:
  Africa
• Volume:
  19
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:13843619921c0b2fc8e7a7b7d3d6d3f0e00772457bff1c11efc86dac695b43c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/18955/cdc_18955_DS1.pdf
• File Type:
  [PDF - 610.04 KB ]